{"id":"W3120895755","doi":"10.1200/jco.20.01086","title":"Phase II Trial of Costimulation Blockade With Abatacept for Prevention of Acute GVHD","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":249,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Center for Advancing Translational Sciences; National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Heart, Lung, and Blood Institute; U.S. Food and Drug Administration","keywords":"Abatacept; Medicine; Internal medicine; Hazard ratio; Clinical endpoint; Placebo; Calcineurin; Methotrexate; Transplantation; Gastroenterology; Immunology; Clinical trial; Confidence interval; Rituximab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001995268,0.001974121,0.002323126,0.0005659673,0.0004835062,0.000906732,0.0009694933,0.001575878,0.005854183],"category_scores_gemma":[0.001213735,0.0005989627,0.00104641,0.0004300523,0.001064077,0.000812626,0.0003551731,0.003024112,0.001015381],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006657953,"about_ca_system_score_gemma":0.001769323,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006195622,"about_ca_topic_score_gemma":0.0008334944,"domain_scores_codex":[0.9993573,0.0002957605,0.00003849537,0.0001242309,0.00005837175,0.0001259254],"domain_scores_gemma":[0.999113,0.0001595871,0.0001672598,0.00008683043,0.00008953931,0.0003838144],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8947182,0.03905951,0.001421128,0.0006091287,0.0005015514,0.00007861506,0.00007902187,0.0009173907,0.01931247,0.0003907908,0.001956329,0.0409558],"study_design_scores_gemma":[0.8108843,0.1848942,0.001191496,0.00002741835,0.0001255844,0.00004319023,0.00001048507,0.0004518523,0.001286377,0.0001727383,0.0009046799,0.000007680896],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9685845,0.00350186,0.001679897,0.0008026795,0.0007730255,0.01810441,0.002411406,0.00024724,0.003895097],"genre_scores_gemma":[0.9619831,0.001850189,0.004857726,0.001923859,0.000665175,0.02171277,0.002638985,0.00003816671,0.004330075],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005854183,"threshold_uncertainty_score":0.01958424,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1483854092688785,"score_gpt":0.5169486579838362,"score_spread":0.3685632487149577,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}