{"id":"W3120986709","doi":"","title":"A Phase 3, multicenter, open-label, switchover trial to assess the safety and efficacy of taliglucerase alfa, a plant cell-expressed recombinant human glucocerebrosidase, in adult and pediatric patients with Gaucher disease previously treated with imiglucerase","year":2014,"lang":"en","type":"article","venue":"Nouvelle revue francaise d'hématologie/Blood cells","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital","funders":"","keywords":"Medicine; Enzyme replacement therapy; Adverse effect; Glucocerebrosidase; Clinical trial; Regimen; Pediatrics; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001433565,0.001178558,0.001618777,0.0003015941,0.0004462343,0.0007412152,0.0005018949,0.0009571348,0.002285913],"category_scores_gemma":[0.0008983514,0.0003307072,0.001081035,0.0002975823,0.000881227,0.0008903454,0.000285814,0.002882392,0.0004446719],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000749082,"about_ca_system_score_gemma":0.0010861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006654626,"about_ca_topic_score_gemma":0.001335466,"domain_scores_codex":[0.9995157,0.0001820594,0.00002332755,0.0001065292,0.00005438802,0.0001180662],"domain_scores_gemma":[0.9991367,0.0001553471,0.00018529,0.00009865559,0.00006623814,0.0003577779],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7890919,0.07222008,0.01855444,0.0004008348,0.001298752,0.0008110114,0.0005656925,0.001464669,0.04671571,0.0003282134,0.002825872,0.06572276],"study_design_scores_gemma":[0.3538847,0.6161032,0.02165153,0.00002167185,0.000298657,0.0005770712,0.00008929027,0.0009630969,0.004460938,0.0001882081,0.001734151,0.00002754432],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972336,0.0005249468,0.0002508711,0.0001196119,0.00004293381,0.0008117004,0.0004856219,0.00002976974,0.0005010733],"genre_scores_gemma":[0.9938349,0.0004848201,0.0009444599,0.0005313978,0.000103028,0.001411564,0.001754841,0.00001865445,0.0009162233],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002285913,"threshold_uncertainty_score":0.007647216,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02116893413508515,"score_gpt":0.2805479282776878,"score_spread":0.2593789941426026,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}