{"id":"W3121005249","doi":"10.1016/j.tru.2020.100030","title":"Novel biomarkers to detect occult cancer in patients with unprovoked venous thromboembolism: Rationale and design of the PLATO-VTE study","year":2021,"lang":"en","type":"article","venue":"Thrombosis Update","topic":"Venous Thromboembolism Diagnosis and Management","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"LEO Pharma; Bayer HealthCare; Trombosestichting Nederland; Sanofi; Roche; Servier; Daiichi-Sankyo; Pfizer; Daiichi Sankyo Europe; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Medicine; Cancer; Internal medicine; Biomarker; Prospective cohort study; Cancer screening; Intensive care medicine; Venous thromboembolism; Oncology; Thrombosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03591914,0.00228042,0.002932183,0.001260647,0.001154421,0.002048651,0.001795419,0.002000949,0.003203313],"category_scores_gemma":[0.0253905,0.001498499,0.001918362,0.001658938,0.001938344,0.001470011,0.001876781,0.002504651,0.001787223],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009015567,"about_ca_system_score_gemma":0.003948498,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006612596,"about_ca_topic_score_gemma":0.0008166536,"domain_scores_codex":[0.9857976,0.009700518,0.001070938,0.001377399,0.001390269,0.0006633822],"domain_scores_gemma":[0.9906936,0.002926619,0.001417828,0.001446446,0.002077204,0.001438326],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"not_applicable","study_design_scores_codex":[0.4355287,0.03034839,0.3761584,0.005432122,0.003630049,0.0009924461,0.00177779,0.005157928,0.01182081,0.01142159,0.008253213,0.1094786],"study_design_scores_gemma":[0.1702445,0.4165306,0.2403551,0.002676815,0.008631681,0.001947094,0.001399864,0.01517385,0.01122816,0.01437834,0.1169083,0.0005257476],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.5297301,0.02019329,0.04674287,0.004070216,0.002994751,0.3700063,0.009317136,0.0002190769,0.01672628],"genre_scores_gemma":[0.544726,0.005363653,0.06557756,0.004320015,0.00175957,0.3707077,0.004487729,0.00009075964,0.00296709],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.03591914,"threshold_uncertainty_score":0.1899608,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02301549315124137,"score_gpt":0.2694623858775419,"score_spread":0.2464468927263005,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}