{"id":"W3121057262","doi":"10.25251/skin.5.supp.3","title":"Interim Analysis of Phase 2 Results for Cemiplimab in Patients with Metastatic Basal Cell Carcinoma (mBCC) who Progressed on or are Intolerant to Hedgehog Inhibitors (HHIs)","year":2021,"lang":"en","type":"article","venue":"SKIN The Journal of Cutaneous Medicine","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"Regeneron Pharmaceuticals; Sanofi","keywords":"Basal cell carcinoma; Interim; Vismodegib; Internal medicine; Oncology; Medicine; Interim analysis; Basal cell; Clinical trial; History","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006770986,0.001414536,0.002481957,0.0003914651,0.0005128598,0.001951018,0.0006701825,0.001281196,0.005768141],"category_scores_gemma":[0.004363612,0.0004665195,0.003219464,0.0004474118,0.0005434852,0.00128853,0.0004941855,0.003460527,0.001073513],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009549846,"about_ca_system_score_gemma":0.001364566,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004143321,"about_ca_topic_score_gemma":0.001467981,"domain_scores_codex":[0.9980382,0.001169797,0.00008094083,0.000150309,0.0001414748,0.0004192954],"domain_scores_gemma":[0.9973511,0.0009904595,0.0005490422,0.0003052572,0.00014422,0.0006599538],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.876623,0.004881133,0.0134871,0.0007787299,0.004169203,0.0003362632,0.0001609572,0.006291519,0.009681497,0.0005747555,0.01312549,0.06989045],"study_design_scores_gemma":[0.4758509,0.3787997,0.09857503,0.0002629787,0.006730678,0.0009240982,0.000238927,0.007500871,0.0087709,0.003169282,0.019042,0.0001347197],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9531235,0.008416455,0.00359782,0.002503643,0.0007849182,0.004294375,0.01488149,0.0003193253,0.01207853],"genre_scores_gemma":[0.9712248,0.0015086,0.003046038,0.002443037,0.0002970299,0.004292173,0.0120414,0.0001120072,0.005035016],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006770986,"threshold_uncertainty_score":0.0358088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01888602988988578,"score_gpt":0.2952838839229059,"score_spread":0.2763978540330201,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}