{"id":"W3121057262","doi":"10.25251/skin.5.supp.3","title":"Interim Analysis of Phase 2 Results for Cemiplimab in Patients with Metastatic Basal Cell Carcinoma (mBCC) who Progressed on or are Intolerant to Hedgehog Inhibitors (HHIs)","year":2021,"lang":"en","type":"article","venue":"SKIN The Journal of Cutaneous Medicine","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"Regeneron Pharmaceuticals; Sanofi","keywords":"Basal cell carcinoma; Interim; Vismodegib; Internal medicine; Oncology; Medicine; Interim analysis; Basal cell; Clinical trial; History","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006150085,0.0002274856,0.0007735722,0.0003000014,0.00005363309,0.000007473439,0.0002494901,0.00005698867,0.000009575705],"category_scores_gemma":[0.001069438,0.0001221478,0.0001420246,0.0006335467,0.0001354289,0.000003835395,0.00006716949,0.0001674897,3.410193e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005171678,"about_ca_system_score_gemma":0.000166703,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001170155,"about_ca_topic_score_gemma":0.000171775,"domain_scores_codex":[0.9979855,0.0001965971,0.0008849313,0.0002464137,0.0004358201,0.0002507574],"domain_scores_gemma":[0.9977557,0.0002640203,0.0007232121,0.000347373,0.0007905083,0.0001191944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.2353245,0.009366279,0.02883331,0.001263964,0.009653066,0.003553312,0.03061993,0.02600154,0.6168078,0.000005767344,0.02305401,0.0155165],"study_design_scores_gemma":[0.03162481,0.05408701,0.009028679,0.002062126,0.004398518,0.0002395073,0.007456611,0.000737257,0.8866415,0.0000175943,0.003126314,0.0005800503],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974299,0.0005866867,0.0005488606,0.0007576163,0.0001564851,0.0003693122,0.00008987979,0.000001801916,0.00005947377],"genre_scores_gemma":[0.9988502,0.00004570146,0.0003995207,0.0003372983,0.0001598953,0.000007864739,0.00005575575,0.00002444673,0.000119326],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2698337,"threshold_uncertainty_score":0.4981042,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01888602988988578,"score_gpt":0.2952838839229059,"score_spread":0.2763978540330201,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}