{"id":"W3121101059","doi":"10.1093/ofid/ofaa417.004","title":"5. How Does Frailty Impact the Efficacy, Reactogenicity, Immunogenicity and Safety of the Adjuvanted Recombinant Zoster Vaccine? A Secondary Analysis of the ZOE-50 and ZOE-70 Studies","year":2020,"lang":"en","type":"article","venue":"Open Forum Infectious Diseases","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nova Scotia Health Authority; Izaak Walton Killam Health Centre; Dalhousie University","funders":"","keywords":"Reactogenicity; Medicine; Adverse effect; Placebo; Immunogenicity; Chills; Pediatrics; Internal medicine; Immunology; Alternative medicine; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001977788,0.0002934496,0.0008537374,0.00008310559,0.0005640663,0.0001064191,0.0003010676,0.00007652293,0.0001175223],"category_scores_gemma":[0.0005333911,0.0001147172,0.0006022223,0.0008900127,0.0003018167,0.0001989671,0.001044878,0.0002395058,0.000001033755],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008488112,"about_ca_system_score_gemma":0.0001714087,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001497234,"about_ca_topic_score_gemma":0.001623737,"domain_scores_codex":[0.9984378,0.0002719417,0.0004235555,0.0003602991,0.0002461696,0.000260205],"domain_scores_gemma":[0.9981739,0.0004056263,0.0003890878,0.0007069745,0.000179074,0.0001453165],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006324874,0.0004829731,0.974043,0.00007368033,0.01011269,0.000003024818,0.0005081154,0.00001233501,0.0003796769,0.00005777489,0.000606325,0.01308793],"study_design_scores_gemma":[0.003644716,0.000455092,0.9839864,0.0001230976,0.006900698,0.00002302618,0.0007126348,0.00008665682,0.001344431,0.0002136332,0.002363544,0.000146098],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894534,0.002348289,0.000007101878,0.005551949,0.0001509535,0.00146026,0.000505023,0.00002483651,0.0004981519],"genre_scores_gemma":[0.9980325,0.001006011,0.000004353597,0.000690765,0.00002004424,0.00004611597,0.00001893188,0.00002233339,0.0001589086],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01294183,"threshold_uncertainty_score":0.4678031,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02419983879825947,"score_gpt":0.3118432912773867,"score_spread":0.2876434524791272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}