{"id":"W3121138262","doi":"10.18433/jpps31349","title":"Cell Cycle Arrest and Apoptosis Induction by a New 2,4-Dinitrobenzenesulfonamide Derivative In Acute Leukemia Cells","year":2021,"lang":"en","type":"article","venue":"Journal of Pharmacy & Pharmaceutical Sciences","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Universidade Federal de Santa Catarina; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Jurkat cells; Apoptosis; K562 cells; Cytotoxic T cell; Survivin; Cell biology; Programmed cell death; Cell cycle; Cell cycle checkpoint; Flow cytometry; Biology; Chemistry; Cancer research; Immunology; T cell; Biochemistry; Immune system; In vitro","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000957527,0.0002658016,0.0001816767,0.0001796093,0.0001137803,0.0001127514,0.0001324781,0.000122971,0.0007477126],"category_scores_gemma":[0.00007330278,0.00005187341,0.0001484808,0.0001245923,0.0001090191,0.0001070434,0.00009395944,0.0001756414,0.0001640061],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000186831,"about_ca_system_score_gemma":0.0001735468,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000496017,"about_ca_topic_score_gemma":0.0007852434,"domain_scores_codex":[0.9999348,0.00001429738,0.000008055211,0.00001126179,0.00001922628,0.00001238508],"domain_scores_gemma":[0.999935,0.00001342379,0.00002396253,0.00000582405,0.00001102452,0.00001075653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001801066,0.00004214439,0.0003828578,0.0000815502,0.000004351495,0.00004801946,0.00002123039,0.0002063731,0.9962047,0.00006012774,0.00002983257,0.002738694],"study_design_scores_gemma":[0.00002936294,0.001579084,0.004307787,0.0000100278,0.00001606581,0.0002213612,0.00002249631,0.0007257428,0.9906877,0.00002979552,0.002366604,0.00000398495],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958904,0.002472745,0.0007842343,0.00003059268,0.0000102157,0.00001850182,0.00009393259,0.00002555878,0.0006738087],"genre_scores_gemma":[0.9957586,0.001946967,0.001072092,0.00002090016,0.000007255742,0.00002456443,0.0002511624,0.000004953979,0.0009134164],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007477126,"threshold_uncertainty_score":0.002501369,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02615275931369373,"score_gpt":0.3284409097241682,"score_spread":0.3022881504104745,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}