{"id":"W3121184362","doi":"10.1038/s41588-020-00762-2","title":"Shared genetic pathways contribute to risk of hypertrophic and dilated cardiomyopathies with opposite directions of effect","year":2021,"lang":"en","type":"review","venue":"Nature Genetics","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":292,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University; Université de Montréal; Montreal Heart Institute","funders":"National Cancer Institute; NIH Office of the Director; National Institute on Drug Abuse; NIHR Oxford Biomedical Research Centre; Engineering and Physical Sciences Research Council; Medical Research Council; Canadian Institutes of Health Research; Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers; National Institute of Mental Health; Horizon 2020 Framework Programme; Mason Medical Research Trust; Klaus Tschira Stiftung; Wellcome Trust; Imperial College Healthcare NHS Trust; BHF Centre of Research Excellence, Oxford; Stichting Volksbond Rotterdam; Fédération Française de Cardiologie; Università degli Studi di Firenze; ZonMw; Common Fund; Netherlands Heart Institute; Japan Society for the Promotion of Science; Deutsches Zentrum für Herz-Kreislaufforschung; Heart Rhythm Society; Imperial College London; Fondation Institut de Cardiologie de Montréal; UK Research and Innovation; National Institute for Health and Care Research; Agence Nationale de la Recherche; Fondation Leducq; National Human Genome Research Institute; UK Dementia Research Institute; Amsterdam University Medical Centers; National Institutes of Health; European Research Area Network on Cardiovascular Diseases; Rosetrees Trust; European Commission; European Society of Cardiology; National Heart, Lung, and Blood Institute; Academy of Medical Sciences; National Institute of Neurological Disorders and Stroke; British Heart Foundation; Institut de Cardiologie de Montréal; Heart and Stroke Foundation of Canada","keywords":"Hypertrophic cardiomyopathy; Dilated cardiomyopathy; Genome-wide association study; Mendelian randomization; Internal medicine; Biology; Cardiology; Heart failure; Biobank; Genetics; Genotype; Genetic variants; Gene; Medicine; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005574843,0.0009317501,0.001690595,0.00113581,0.0001115424,0.000648984,0.0006756017,0.001044556,0.002223014],"category_scores_gemma":[0.001113571,0.0001675525,0.0006826235,0.001083437,0.0003460967,0.0004334831,0.0004582629,0.000930692,0.0004869442],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000267665,"about_ca_system_score_gemma":0.0005653266,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007337151,"about_ca_topic_score_gemma":0.0009917902,"domain_scores_codex":[0.9997914,0.00004482786,0.00003178595,0.00006426183,0.00005242602,0.00001517342],"domain_scores_gemma":[0.9994923,0.0003555297,0.00006050761,0.0000128569,0.0000581032,0.00002065927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004243733,0.00005660064,0.004470896,0.01407833,0.001428108,0.001189116,0.00005569879,0.0004925159,0.002506799,0.005350477,0.01525855,0.9546885],"study_design_scores_gemma":[0.0004404873,0.0004572599,0.04029955,0.02289846,0.00893191,0.01656674,0.0003075544,0.000623479,0.002271991,0.02156766,0.8854663,0.0001685213],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004444989,0.9980291,0.0002773125,0.0003989417,0.0001426282,0.000002808413,0.00004359317,0.000007490572,0.0006535908],"genre_scores_gemma":[0.003309251,0.9949796,0.0005064906,0.0003146315,0.0003996394,0.00000698841,0.00008158293,0.000001964236,0.0003999493],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002223014,"threshold_uncertainty_score":0.007436752,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01312505220708327,"score_gpt":0.2773408998950582,"score_spread":0.264215847687975,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}