{"id":"W3121214078","doi":"10.1038/s41467-020-20508-2","title":"Chromosome-level genome assembly of Ophiorrhiza pumila reveals the evolution of camptothecin biosynthesis","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":131,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Chiba University; Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology; National University of Singapore; Research Organization of Information and Systems; Japan Agency for Medical Research and Development","keywords":"Camptothecin; Genome; Chromosome; Biology; Gene; Genetics; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002473928,0.00009173938,0.0001464794,0.00003486076,0.0001079738,0.000007666352,0.0007427807,0.0002297568,0.00001679105],"category_scores_gemma":[0.000117505,0.00007598691,0.000119647,0.0002380883,0.0001035298,0.000002736137,0.0003073879,0.0002036292,0.000001588379],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003668083,"about_ca_system_score_gemma":0.000209948,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002694071,"about_ca_topic_score_gemma":0.0003041261,"domain_scores_codex":[0.9992417,0.0001429881,0.0002330995,0.0001528211,0.0001180351,0.000111376],"domain_scores_gemma":[0.9975287,0.00007292996,0.0001683966,0.001857883,0.0003439999,0.00002805699],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001020541,0.00008739593,0.0001036016,0.0000133081,0.00008105743,1.258967e-7,0.00005076695,0.000007197129,0.9836427,0.01531318,0.000159078,0.0005313642],"study_design_scores_gemma":[0.0001941348,0.00005509775,0.003731658,0.00003219638,0.00006689421,0.00001132444,0.0003306451,0.00002924571,0.9478522,0.0006313274,0.04695384,0.0001114616],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8475875,0.1309423,0.004586465,0.006205832,0.0004013621,0.0006088769,0.00117737,0.00002116071,0.008469072],"genre_scores_gemma":[0.9922634,0.003585789,0.003337516,0.0001946618,0.00005373073,0.00002173316,0.0001698648,0.00001587955,0.0003574527],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1446758,"threshold_uncertainty_score":0.3098657,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02475277975020022,"score_gpt":0.2879424178575099,"score_spread":0.2631896381073097,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}