{"id":"W3121343412","doi":"10.1038/s41375-021-01137-0","title":"Germline variants drive myelodysplastic syndrome in young adults","year":2021,"lang":"en","type":"letter","venue":"Leukemia","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":65,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Heart, Lung, and Blood Institute; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Germline; Myelodysplastic syndromes; Medicine; Germline mutation; Oncology; Genetics; Internal medicine; Biology; Mutation; Gene; Bone marrow","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["research_integrity","insufficient_payload"],"category_scores_codex":[0.0004236547,0.0009150314,0.001815477,0.001049192,0.00009627941,0.0001047741,0.0006996026,0.002654721,0.001673305],"category_scores_gemma":[0.0009480496,0.0008851095,0.0003868546,0.001289737,0.0002333061,0.0001660944,0.0005026981,0.009609832,0.001449049],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.007307061,"about_ca_system_score_gemma":0.004896356,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001395653,"about_ca_topic_score_gemma":0.0003150166,"domain_scores_codex":[0.9936113,0.0003166576,0.001093185,0.001668158,0.001579928,0.001730746],"domain_scores_gemma":[0.9967048,0.0006064551,0.0002871173,0.00166611,0.0003938877,0.0003415957],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002916849,0.00006511823,0.003265145,0.001738363,0.0003514683,0.1917067,0.0002992432,0.0000199724,0.0002806727,0.0000158181,0.8011399,0.0008259129],"study_design_scores_gemma":[0.03453466,0.001817793,0.271381,0.02129576,0.001456936,0.06756297,0.0003815953,0.01160129,0.0004441925,0.0003283344,0.5845284,0.004667151],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.3871155,0.002086156,0.0002746568,0.5746409,0.003423678,0.003800705,0.0004941024,0.0005786011,0.02758571],"genre_scores_gemma":[0.194555,0.001189107,0.003494823,0.6563803,0.01276841,0.0006899059,0.01094754,0.001012237,0.1189628],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.2681158,"threshold_uncertainty_score":0.99936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01417332623384934,"score_gpt":0.2632150325087246,"score_spread":0.2490417062748753,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}