{"id":"W3121343412","doi":"10.1038/s41375-021-01137-0","title":"Germline variants drive myelodysplastic syndrome in young adults","year":2021,"lang":"en","type":"letter","venue":"Leukemia","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":65,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Heart, Lung, and Blood Institute; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Germline; Myelodysplastic syndromes; Medicine; Germline mutation; Oncology; Genetics; Internal medicine; Biology; Mutation; Gene; Bone marrow","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006740094,0.0003344083,0.0004516706,0.0005168925,0.002365566,0.001071134,0.000445844,0.01201618,0.004545205],"category_scores_gemma":[0.005959922,0.0003041765,0.0003782369,0.0003834301,0.001061267,0.000729234,0.00062937,0.00572293,0.001851065],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001211075,"about_ca_system_score_gemma":0.00157543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005864143,"about_ca_topic_score_gemma":0.008573995,"domain_scores_codex":[0.9993907,0.000169771,0.00006964379,0.00007930265,0.0001277969,0.0001626307],"domain_scores_gemma":[0.9980791,0.001066882,0.0001683941,0.00004411513,0.0001885468,0.000452996],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.0002637086,0.0001755061,0.09308966,0.0001093312,0.00005886959,0.1808763,0.001184868,0.0002860317,0.002609229,0.00977222,0.6734818,0.03809254],"study_design_scores_gemma":[0.0004452592,0.0005388688,0.05103827,0.0009668809,0.0001965702,0.3461283,0.003889635,0.002198343,0.002258836,0.02766227,0.564562,0.0001147459],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.03817403,0.004102631,0.0003025223,0.9098671,0.01165084,0.00003413915,0.000277783,0.00007763616,0.0355133],"genre_scores_gemma":[0.2453476,0.005148841,0.0008599216,0.6734162,0.04616906,0.00005631052,0.000209843,0.00008213825,0.02871008],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01201618,"threshold_uncertainty_score":0.01520526,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01417332623384934,"score_gpt":0.2632150325087246,"score_spread":0.2490417062748753,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}