{"id":"W3121348835","doi":"10.3389/fnagi.2020.585873","title":"Early Long-Term Memory Impairment and Changes in the Expression of Synaptic Plasticity-Associated Genes, in the McGill-R-Thy1-APP Rat Model of Alzheimer's-Like Brain Amyloidosis","year":2021,"lang":"en","type":"article","venue":"Frontiers in Aging Neuroscience","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"McGill University; Agencia Nacional de Promoción Científica y Tecnológica; Canadian Institutes of Health Research; Secretaría de Ciencia y Técnica, Universidad de Buenos Aires; Universidad de Buenos Aires; Consortium canadien en neurodégénérescence associée au vieillissement","keywords":"Neuroscience; Hippocampus; Synaptic plasticity; Amyloid precursor protein; Psychology; Habituation; Neuroplasticity; Long-term memory; Episodic memory; Long-term potentiation; Amygdala; Alzheimer's disease; Biology; Pathology; Medicine; Disease; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002711588,0.001331016,0.0006273572,0.001122588,0.0003188602,0.0003996813,0.0005711116,0.0008033969,0.001215405],"category_scores_gemma":[0.0001705206,0.0004284704,0.0005659571,0.0002603239,0.0005849684,0.0006643713,0.0004084993,0.001338277,0.0004729757],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004776138,"about_ca_system_score_gemma":0.0003359547,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002269084,"about_ca_topic_score_gemma":0.002815831,"domain_scores_codex":[0.9997041,0.00002379982,0.00003852184,0.00008140589,0.00005161586,0.0001006285],"domain_scores_gemma":[0.9995951,0.00002465211,0.0001277393,0.000038729,0.00003619222,0.0001775491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001348241,0.0005068562,0.0008165281,0.00004396671,0.00001374919,0.0004352834,0.00007021112,0.00006034548,0.9953305,0.00005386873,0.00004539071,0.001275056],"study_design_scores_gemma":[0.0002677949,0.01372583,0.0832417,0.00003924548,0.0001884974,0.003458259,0.0002706051,0.001629038,0.895541,0.0002791963,0.001279529,0.00007932576],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979042,0.0007027459,0.0005397407,0.00006390289,0.00002567666,0.00002664123,0.0002807317,0.00006583262,0.0003905985],"genre_scores_gemma":[0.9944746,0.000669849,0.001352404,0.00007965284,0.00001868824,0.00008214454,0.0004822508,0.00003381335,0.002806536],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002269084,"threshold_uncertainty_score":0.004511774,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0328532451237352,"score_gpt":0.2871101474805259,"score_spread":0.2542569023567907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}