{"id":"W3121348835","doi":"10.3389/fnagi.2020.585873","title":"Early Long-Term Memory Impairment and Changes in the Expression of Synaptic Plasticity-Associated Genes, in the McGill-R-Thy1-APP Rat Model of Alzheimer's-Like Brain Amyloidosis","year":2021,"lang":"en","type":"article","venue":"Frontiers in Aging Neuroscience","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"McGill University; Agencia Nacional de Promoción Científica y Tecnológica; Canadian Institutes of Health Research; Secretaría de Ciencia y Técnica, Universidad de Buenos Aires; Universidad de Buenos Aires; Consortium canadien en neurodégénérescence associée au vieillissement","keywords":"Neuroscience; Hippocampus; Synaptic plasticity; Amyloid precursor protein; Psychology; Habituation; Neuroplasticity; Long-term memory; Episodic memory; Long-term potentiation; Amygdala; Alzheimer's disease; Biology; Pathology; Medicine; Disease; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006018847,0.0001609345,0.0003231741,0.0002570602,0.00009920916,0.00002007647,0.0002788968,0.00005158757,0.000001783184],"category_scores_gemma":[0.0002259796,0.0001047992,0.00005206207,0.0007694421,0.0003312275,0.0001173982,0.0001339115,0.0002376615,2.157434e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006277726,"about_ca_system_score_gemma":0.0001257458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007998231,"about_ca_topic_score_gemma":0.00006337412,"domain_scores_codex":[0.997846,0.000397067,0.000277904,0.0004022604,0.000671462,0.0004053228],"domain_scores_gemma":[0.9992575,0.0001963206,0.0001169592,0.0002920073,0.0000453525,0.00009182952],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003235342,0.002586366,0.8397049,0.0001991655,0.000221681,0.00120722,0.004993962,0.001166616,0.1452018,0.00001186121,0.0006703036,0.003712586],"study_design_scores_gemma":[0.003283037,0.0005556114,0.9152865,0.000799769,0.0002446522,0.0000361573,0.00143264,0.03095366,0.04710937,0.00009035864,0.000002945822,0.0002053251],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941297,0.004077736,0.0001123743,0.0009451648,0.0001223749,0.0005370766,0.00004719026,0.00000897684,0.00001945696],"genre_scores_gemma":[0.9985059,0.0006129337,0.0001738516,0.0006144466,0.000006951875,0.00005789182,0.000006716849,0.00001123373,0.00001000076],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0980924,"threshold_uncertainty_score":0.4273588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0328532451237352,"score_gpt":0.2871101474805259,"score_spread":0.2542569023567907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}