{"id":"W3121425442","doi":"10.1038/s41416-020-01185-w","title":"CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers","year":2021,"lang":"en","type":"article","venue":"British Journal of Cancer","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Université Laval; Centre hospitalier universitaire de Québec; McGill University; University of Toronto; Royal Victoria Hospital; Queen's University; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Medical Research and Materiel Command; Servicio Gallego de Salud; Robert Bosch Stiftung; Programme Grants for Applied Research; Instituto de Salud Carlos III; Itä-Suomen Yliopisto; Eberhard Karls Universität Tübingen; Cancer Council Tasmania; World Cancer Research Fund; Medical Research Council; European Commission; Canadian Institutes of Health Research; Ministry of Science and Higher Education of the Russian Federation; U.S. Army; Division of Cancer Prevention, National Cancer Institute; National Institutes of Health; Hellenic Health Foundation; Deutschen Konsortium für Translationale Krebsforschung; Universitätsklinikum Hamburg-Eppendorf; Xunta de Galicia; Rheinische Friedrich-Wilhelms-Universität Bonn; Mutuelle Générale de l'Education Nationale; Institut Gustave-Roussy; Ministero dello Sviluppo Economico; Deutsche Krebshilfe; National Health and Medical Research Council; Oulun Yliopisto; Cancer Institute NSW; Medizinischen Hochschule Hannover; National Institute for Health and Care Research; Centers for Disease Control and Prevention; Centre International de Recherche sur le Cancer; Kreftforeningen; Cancer Council South Australia; Institut National Du Cancer; Leids Universitair Medisch Centrum; Karolinska Institutet; Associazione Italiana per la Ricerca sul Cancro; KWF Kankerbestrijding; Vetenskapsrådet; Norges Forskningsråd; Stockholms Läns Landsting; Ligue Contre le Cancer; Kuopion Yliopistollinen Sairaala; Fonds Wetenschappelijk Onderzoek; Cancer Australia; Russian Foundation for Basic Research; Freistaat Sachsen; University of Technology Sydney; University of Crete; Institut National de la Santé et de la Recherche Médicale; Wellcome Trust; Agence Nationale de la Recherche; University of Southern California; Cancerfonden; Ministerio de Sanidad, Servicios Sociales e Igualdad; European Regional Development Fund; National Cancer Institute; Cancer Council Western Australia; Academy of Finland; Gentofte Hospital; King's College London; Génome Québec; Fondation du cancer du sein du Québec; University of Cambridge; Government of Canada; Stavros Niarchos Foundation; Fondation de France; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Ministerio de Economía y Competitividad; Ovarian Cancer Research Fund; Bundesministerium für Bildung und Forschung; National Breast Cancer Foundation; Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; National Institute of Environmental Health Sciences; Swedish Cancer Foundation; Agency for Science, Technology and Research; Lon V. Smith Foundation; Ministère du Développement Économique, de l’Innovation et de l’Exportation; University of California; McGill University Health Centre; David F. and Margaret T. Grohne Family Foundation; Genome Canada; Sundhed og Sygdom, Det Frie Forskningsråd; Deutsches Krebsforschungszentrum; Université Laval; Cancer Council Victoria; California Department of Public Health; Brigham and Women's Hospital; University of Sydney; Cancer Research UK; Deutsche Gesetzliche Unfallversicherung; Deutsche Forschungsgemeinschaft; Breast Cancer Research Foundation; McGill University; University of California, San Francisco; U.S. Department of Health and Human Services; Cancer Council NSW; Susan G. Komen for the Cure","keywords":"Oestrogen receptor; Internal medicine; Medicine; Breast cancer; Endocrinology; Allele; Progesterone receptor; Hormone; Hormone receptor; Mammary gland; Gynecology; Biology; Cancer; Estrogen receptor; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005541259,0.0004727936,0.0004239213,0.0007650648,0.000325038,0.0005748492,0.0003777883,0.0007307283,0.003572905],"category_scores_gemma":[0.001874763,0.0002316138,0.0007675827,0.0009925095,0.0003038566,0.0001259635,0.0002516118,0.0005727098,0.0003682908],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000170129,"about_ca_system_score_gemma":0.0002270702,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00454041,"about_ca_topic_score_gemma":0.002282839,"domain_scores_codex":[0.9994124,0.0001976675,0.00004798498,0.0001978359,0.00007634224,0.00006766935],"domain_scores_gemma":[0.9984664,0.0004962506,0.0005430086,0.0001482167,0.0001243178,0.0002218985],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001561953,0.00006724136,0.9860992,0.00002960843,0.0005658415,0.0004719305,0.00006263593,0.0001322647,0.007237865,0.00008020186,0.0002373777,0.003453926],"study_design_scores_gemma":[0.00004402634,0.0001136884,0.9970911,0.000006942449,0.000335975,0.0006267185,0.00003335198,0.0005019276,0.0007849469,0.0001379883,0.0003179879,0.000005374807],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978986,0.0006739509,0.0003986834,0.0001388347,0.00002546416,0.000007961051,0.0003886999,0.0000162982,0.0004515829],"genre_scores_gemma":[0.9992831,0.00009807628,0.0001540212,0.00003867967,0.00002472821,0.000004525112,0.0001597116,0.000006573986,0.0002304469],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00454041,"threshold_uncertainty_score":0.01195258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004149702866736928,"score_gpt":0.2252127038458942,"score_spread":0.2210630009791573,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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