{"id":"W3121440810","doi":"10.1101/2021.01.19.427220","title":"Ectopic FVIII expression and misfolding in hepatocytes as a cause for hepatocellular carcinoma","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health","keywords":"Hepatocellular carcinoma; Endoplasmic reticulum; Context (archaeology); Viral vector; Hepatocyte; Cancer research; Clotting factor; Ectopic expression; Biology; Gene; Cell biology; Recombinant DNA; Medicine; Internal medicine; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001552288,0.0004444227,0.0002972024,0.0005117713,0.0001331742,0.000270399,0.0002149656,0.0003956184,0.01036224],"category_scores_gemma":[0.0001073946,0.0001451935,0.000253154,0.0004455709,0.0001495968,0.0001893368,0.0001826865,0.0007037098,0.001570272],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004404748,"about_ca_system_score_gemma":0.0001468435,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005150727,"about_ca_topic_score_gemma":0.0004817967,"domain_scores_codex":[0.9998714,0.00001671638,0.000005253825,0.00002464769,0.00005991985,0.00002204463],"domain_scores_gemma":[0.99994,0.000009511869,0.00002395381,0.000005641264,0.000008628174,0.00001231112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003461626,0.00008267624,0.000731388,0.0007415148,0.00005755539,0.0005373936,0.00003784479,0.0007706854,0.9641787,0.001889783,0.008411078,0.02221522],"study_design_scores_gemma":[0.00005722294,0.0003698304,0.00630486,0.00008146246,0.00007365573,0.0009445892,0.00005252194,0.003813688,0.9455889,0.0009797537,0.04171026,0.0000231864],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8100559,0.03842252,0.07177975,0.01060494,0.002206091,0.0005859449,0.01795205,0.003858796,0.04453398],"genre_scores_gemma":[0.9477688,0.01227463,0.01035363,0.0006504935,0.0001691625,0.0001248337,0.003482416,0.00009626745,0.02507978],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01036224,"threshold_uncertainty_score":0.03466517,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03300033855833252,"score_gpt":0.2732459247717643,"score_spread":0.2402455862134318,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}