{"id":"W3121517897","doi":"10.3389/ffunb.2020.614633","title":"DNA Methylation Is Responsive to the Environment and Regulates the Expression of Biosynthetic Gene Clusters, Metabolite Production, and Virulence in Fusarium graminearum","year":2021,"lang":"en","type":"article","venue":"Frontiers in Fungal Biology","topic":"Plant Pathogens and Fungal Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University; Agriculture and Agri-Food Canada","funders":"Agriculture and Agri-Food Canada","keywords":"Biology; Epigenetics; Methyltransferase; DNA methylation; Gene; Genetics; Methylation; Neurospora crassa; Mutant; Histone; Secondary metabolite; Gene expression; Fusarium; Regulation of gene expression; Virulence; Demethylase; Histone methylation; DNA; Bisulfite sequencing; Histone methyltransferase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002925673,0.0001070167,0.000157402,0.0000565818,0.00005655485,0.000008142446,0.00009226172,0.00009938934,0.000001991471],"category_scores_gemma":[0.000225927,0.00006867743,0.00002776593,0.0001032555,0.0001694948,0.000004513639,0.0001637195,0.00006547614,4.148255e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009120058,"about_ca_system_score_gemma":0.00002662409,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009376226,"about_ca_topic_score_gemma":0.000009781589,"domain_scores_codex":[0.9989281,0.0003203394,0.0001847218,0.0003576231,0.00005371638,0.0001554794],"domain_scores_gemma":[0.9995859,0.00002895479,0.00006077356,0.0002622342,0.00002690031,0.00003528635],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001760432,0.00002381153,0.03709958,0.000008037245,0.00001522704,0.000002172855,0.0001752121,0.00004985171,0.9599443,0.00001270271,0.0003149818,0.00217806],"study_design_scores_gemma":[0.0001372515,0.0000820296,0.09750381,0.000009543964,0.00001935903,0.00001303562,0.0003078259,0.00005894878,0.8953079,0.0001658419,0.006305272,0.00008919757],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9775972,0.0192684,0.000558727,0.001690859,0.0002150974,0.0002313197,0.0004272473,0.000001807894,0.00000931112],"genre_scores_gemma":[0.9945941,0.003111357,0.001679652,0.0003179094,0.00004735657,0.00002526223,0.0001250096,0.000006476808,0.00009289369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06463643,"threshold_uncertainty_score":0.2800584,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006163762077205936,"score_gpt":0.2089370573550114,"score_spread":0.2027732952778055,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}