{"id":"W3121522776","doi":"10.1101/2021.01.15.426914","title":"Tonic activity in lateral habenula neurons promotes disengagement from reward-seeking behavior","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Ventral tegmental area; Disengagement theory; Habenula; Tonic (physiology); Psychology; Brain stimulation reward; Neuroscience; Reward system; Dopamine; Dopaminergic; Nucleus accumbens; Central nervous system; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008969807,0.0001667426,0.0002263036,0.0001669112,0.0001516843,0.0003531621,0.0001387239,0.0001805532,0.002095762],"category_scores_gemma":[0.0001393257,0.0001210267,0.000166102,0.00006637328,0.0003178604,0.000236823,0.000365393,0.0006635813,0.0003513041],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000339961,"about_ca_system_score_gemma":0.0002141826,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00106312,"about_ca_topic_score_gemma":0.003205876,"domain_scores_codex":[0.9999261,0.000006115681,0.000006000104,0.0000171397,0.00002042215,0.00002432762],"domain_scores_gemma":[0.9998715,0.00001294825,0.00003589845,0.00001257125,0.00001158407,0.00005556255],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001024028,0.00001133248,0.001240682,0.00001470633,0.000006266077,0.00003404029,0.00001526866,0.00003423204,0.9975455,0.00009097864,0.00003781052,0.000866665],"study_design_scores_gemma":[0.00003178974,0.0003449379,0.1925877,0.00002030465,0.00002068927,0.0003560706,0.0001598872,0.002727201,0.8014265,0.0005691508,0.001739815,0.00001592044],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974124,0.0002525026,0.001127563,0.00008246292,0.00001391608,0.000003630344,0.0001509727,0.00004087575,0.0009157846],"genre_scores_gemma":[0.996673,0.0001163557,0.0005826271,0.000038516,0.000007210845,0.00001027883,0.0001788758,0.00001645215,0.002376742],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002095762,"threshold_uncertainty_score":0.007010996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03422195291169586,"score_gpt":0.2613527699632901,"score_spread":0.2271308170515942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}