{"id":"W3121527289","doi":"10.1016/j.yexcr.2021.112854","title":"NFATc1 promotes epithelial-mesenchymal transition and facilitates colorectal cancer metastasis by targeting SNAI1","year":2021,"lang":"en","type":"article","venue":"Experimental Cell Research","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"York University","funders":"Key Science and Technology Program of Shaanxi Province; Science and Technology Innovation as a Whole Plan Projects of Shaanxi Province; National Natural Science Foundation of China","keywords":"SNAI1; Epithelial–mesenchymal transition; Metastasis; Colorectal cancer; Biology; Cancer research; Slug; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004405579,0.0001554887,0.0001345213,0.00003362783,0.0002342528,0.00007123224,0.0001295337,0.0001036792,0.0003619258],"category_scores_gemma":[0.00009773155,0.0001574891,0.00007349871,0.0001443514,0.0002462157,0.000008634626,0.0001803977,0.000170708,0.00001284746],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004699393,"about_ca_system_score_gemma":0.0001612923,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001225947,"about_ca_topic_score_gemma":0.000006577744,"domain_scores_codex":[0.9981211,0.0003560334,0.0001677875,0.0005493037,0.0003809654,0.0004248112],"domain_scores_gemma":[0.9994195,0.00005006003,0.00002462145,0.0001630939,0.0001574939,0.0001853054],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001486647,0.0002626166,0.0002568156,0.00004041957,0.00003914561,0.00002386052,0.0008487131,0.000008094545,0.9938465,0.000004162355,0.004119931,0.0004011112],"study_design_scores_gemma":[0.0005046666,0.0003820414,0.00003457949,0.00001332085,0.000007186411,0.000005362921,0.002932918,0.0000651354,0.9928812,0.00001905285,0.002980714,0.0001737717],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9650053,0.03360173,0.00003940529,0.0001890887,0.00006946005,0.0002414468,0.0003299213,0.00001338683,0.0005102314],"genre_scores_gemma":[0.9978938,0.0003093943,0.0004900719,0.00004833639,0.0001174032,0.0001677992,0.000422141,0.0000278633,0.000523152],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03329234,"threshold_uncertainty_score":0.642222,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02967053932264475,"score_gpt":0.3464147815099812,"score_spread":0.3167442421873365,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}