{"id":"W3121697458","doi":"10.20944/preprints202002.0364.v1","title":"HSP70/IL-2 Treated NK Cells Effectively Cross the Blood Brain Barrier and Target Tumor Cells in a Rat Model of Induced Glioblastoma Multiforme (GBM)","year":2020,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; The Scarborough Hospital; York University; University of Toronto","funders":"","keywords":"In vivo; Cancer research; Interleukin 12; Homing (biology); Lymphokine-activated killer cell; In vitro; Cytotoxic T cell; Cell therapy; Interleukin 21; Immunology; Biology; Stem cell; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0008057519,0.000631563,0.0009143514,0.0002851216,0.0001988985,0.00003598148,0.0005984564,0.000802408,0.0009976721],"category_scores_gemma":[0.0004183468,0.0005275226,0.0003316752,0.0002211421,0.0003501374,0.0001680065,0.001413388,0.002269618,0.0008350181],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001235332,"about_ca_system_score_gemma":0.0002010852,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006194691,"about_ca_topic_score_gemma":0.00004521966,"domain_scores_codex":[0.9963861,0.000821604,0.0009775124,0.00118349,0.0001041686,0.0005271261],"domain_scores_gemma":[0.9977339,0.0004055683,0.0006615503,0.0009192772,0.0002115307,0.00006818272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001797217,0.0003415079,0.02008945,0.0002311695,0.0003842899,0.00001042569,0.002623997,0.001712197,0.9724597,0.00002755307,0.0002438496,0.00007864396],"study_design_scores_gemma":[0.002796242,0.0002159754,0.01499264,0.0001941285,0.0001176653,0.00002556435,0.0002113767,0.002016026,0.9773322,0.0001411769,0.001499566,0.0004574316],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947561,0.0001979448,0.00008803557,0.0002203676,0.002087772,0.001529745,0.0001393892,0.0001259773,0.0008546646],"genre_scores_gemma":[0.9945979,0.00008549887,0.00003685837,0.0003586964,0.00003828243,0.0002405652,0.0001012193,0.00006792681,0.004473115],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005096814,"threshold_uncertainty_score":0.999943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04146220313958535,"score_gpt":0.2873895369294122,"score_spread":0.2459273337898269,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}