{"id":"W3121748875","doi":"10.1021/acschemneuro.0c00754","title":"Inhibition of Amyloid β-Induced Lipid Membrane Permeation and Amyloid β Aggregation by K162","year":2021,"lang":"en","type":"article","venue":"ACS Chemical Neuroscience","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"H2020 Marie Skłodowska-Curie Actions; Natural Sciences and Engineering Research Council of Canada; Narodowe Centrum Nauki","keywords":"Chemistry; Neurodegeneration; Lipid bilayer; Biophysics; Membrane; Amyloid (mycology); Fibril; Permeation; Monomer; Protein aggregation; Cell membrane; Biochemistry; Biology; Polymer; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008561305,0.0003267555,0.0002866556,0.00008896055,0.000112217,0.0001877018,0.0002012769,0.0002927277,0.0008608629],"category_scores_gemma":[0.00009061953,0.0001117362,0.0001978081,0.00008888525,0.0001390689,0.000281346,0.0001687967,0.0003149648,0.0003072561],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000137535,"about_ca_system_score_gemma":0.0001634444,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002855531,"about_ca_topic_score_gemma":0.0003393146,"domain_scores_codex":[0.9999485,0.00000766612,0.000006098932,0.0000116955,0.00001142096,0.00001456362],"domain_scores_gemma":[0.999967,0.000004883505,0.00001056424,0.00000383899,0.000004428737,0.000009246191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000302274,0.0001001462,0.0001181347,0.00007765341,0.00001288842,0.00006482867,0.00001478894,0.0001368627,0.9962619,0.0001285705,0.00008365381,0.002698153],"study_design_scores_gemma":[0.00006258531,0.0008256993,0.000990942,0.000007237491,0.00001274247,0.0002572201,0.00001346413,0.0008212097,0.9943844,0.00003532433,0.002583397,0.000005786023],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951798,0.001886346,0.001099435,0.00009551382,0.00003408789,0.00003821218,0.0001622348,0.00004795771,0.001456433],"genre_scores_gemma":[0.9940842,0.002115556,0.001557627,0.00005764257,0.000008368236,0.00004465194,0.0001697219,0.00001333715,0.001948968],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008608629,"threshold_uncertainty_score":0.002879918,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0248178250076965,"score_gpt":0.29009144538321,"score_spread":0.2652736203755135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}