{"id":"W3121748875","doi":"10.1021/acschemneuro.0c00754","title":"Inhibition of Amyloid β-Induced Lipid Membrane Permeation and Amyloid β Aggregation by K162","year":2021,"lang":"en","type":"article","venue":"ACS Chemical Neuroscience","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"H2020 Marie Skłodowska-Curie Actions; Natural Sciences and Engineering Research Council of Canada; Narodowe Centrum Nauki","keywords":"Chemistry; Neurodegeneration; Lipid bilayer; Biophysics; Membrane; Amyloid (mycology); Fibril; Permeation; Monomer; Protein aggregation; Cell membrane; Biochemistry; Biology; Polymer; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007025017,0.0001047998,0.000164078,0.000043835,0.00006550275,0.00002531517,0.000046292,0.0000576758,0.00002420125],"category_scores_gemma":[0.0004333498,0.00009332505,0.00004015037,0.0003614303,0.0001873992,0.0001963453,0.00006203049,0.0001177597,0.000005975526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003343383,"about_ca_system_score_gemma":0.0001171513,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009508037,"about_ca_topic_score_gemma":4.370935e-7,"domain_scores_codex":[0.9987296,0.00003520528,0.0001783736,0.0003724947,0.000472584,0.0002116827],"domain_scores_gemma":[0.9993078,0.00005407711,0.00006167425,0.0001899432,0.000142926,0.0002435455],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006107031,0.0002724417,0.00193083,0.00004504971,0.00002031143,0.00003261817,0.00003434912,1.774196e-7,0.9957844,0.00002213034,0.0001043705,0.001692273],"study_design_scores_gemma":[0.0009274582,0.0001398176,0.003876353,0.00005879692,0.00005703899,0.00006039218,0.00002210897,0.0002472544,0.994436,0.00005278558,0.00005141744,0.00007058148],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983097,0.0003347512,0.00002149433,0.0006785205,0.00004219014,0.000176638,0.0000217972,0.00002584205,0.0003890243],"genre_scores_gemma":[0.9990907,0.0002802379,0.00007475231,0.0003530027,0.00003824015,0.0000135236,0.00009106059,0.000009471447,0.00004902805],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001945522,"threshold_uncertainty_score":0.3805685,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0248178250076965,"score_gpt":0.29009144538321,"score_spread":0.2652736203755135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}