{"id":"W3121950719","doi":"10.1186/s13287-020-02131-6","title":"Skin regeneration is accelerated by a lower dose of multipotent mesenchymal stromal/stem cells—a paradigm change","year":2021,"lang":"en","type":"article","venue":"Stem Cell Research & Therapy","topic":"Wound Healing and Treatments","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"National Institute of General Medical Sciences; Medizinische Universität Graz; National Institutes of Health; Ontario Institute for Regenerative Medicine; Karl-Franzens-Universität Graz; University of Toronto; Queen's University; Canadian Institutes of Health Research; Sunnybrook Research Institute","keywords":"Mesenchymal stem cell; Stem cell; Wound healing; Regeneration (biology); Medicine; Stromal cell; Multipotent Stem Cell; Cell therapy; Surgery; Pathology; Cell biology; Biology; Progenitor cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004161116,0.0003608443,0.0003156297,0.0002905681,0.0001030206,0.0005723807,0.0002574872,0.0004462947,0.001764354],"category_scores_gemma":[0.0001696354,0.000103818,0.0002623383,0.0001291581,0.0003871004,0.0003512241,0.0002366967,0.0008031868,0.0003094111],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002166124,"about_ca_system_score_gemma":0.0002090768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001247242,"about_ca_topic_score_gemma":0.0002093824,"domain_scores_codex":[0.9997627,0.00005245997,0.00002613619,0.0000522398,0.00008283818,0.00002363314],"domain_scores_gemma":[0.9998422,0.00004400566,0.00004545692,0.00001958343,0.00001994941,0.00002895737],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001331543,0.0001013174,0.0001642817,0.00009224159,0.000005307716,0.00002846808,0.00001727271,0.00007698948,0.9954728,0.0001865556,0.00004191418,0.00367957],"study_design_scores_gemma":[0.00005152697,0.002694315,0.001732761,0.0000203982,0.00003779787,0.0002437736,0.00003814591,0.0004010478,0.991127,0.0001375427,0.00350982,0.000005828931],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986423,0.003524483,0.006979988,0.0005771524,0.0001514945,0.00007265183,0.0001179752,0.00008750371,0.002065683],"genre_scores_gemma":[0.9873054,0.001718583,0.008380014,0.0002359076,0.00008008231,0.00009219474,0.000109167,0.00001765228,0.002060993],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001764354,"threshold_uncertainty_score":0.00590235,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1790565407718684,"score_gpt":0.3868273284155258,"score_spread":0.2077707876436573,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}