{"id":"W3121994210","doi":"10.1007/164_2020_408","title":"Novel Treatment Approaches for Brain Tumour from a Blood–Brain Barrier Perspective","year":2020,"lang":"en","type":"article","venue":"Handbook of experimental pharmacology","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"Blood–brain barrier; Microbubbles; Drug delivery; Medicine; Neuroscience; Drug; Drug delivery to the brain; Central nervous system; Pharmacology; Biology; Chemistry; Ultrasound","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006239096,0.0007235628,0.0008319819,0.001193144,0.0002956213,0.001316812,0.001014563,0.001379818,0.002535547],"category_scores_gemma":[0.0003282189,0.0003555803,0.0005290799,0.0006383321,0.001051023,0.001980218,0.0005462064,0.002720256,0.001152974],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008269555,"about_ca_system_score_gemma":0.0005914932,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005258549,"about_ca_topic_score_gemma":0.001226556,"domain_scores_codex":[0.9998519,0.00003601385,0.000009479229,0.00002427986,0.00005371891,0.0000244102],"domain_scores_gemma":[0.9998707,0.00006780169,0.00001554563,0.000009815477,0.00002298858,0.00001322194],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0002537862,0.0003025549,0.0002138184,0.007446439,0.0001118418,0.0006788264,0.0002870114,0.003148721,0.1575047,0.1300782,0.0316901,0.6682841],"study_design_scores_gemma":[0.0000426042,0.0006637618,0.0008978929,0.0009041411,0.00007899106,0.003207518,0.0001344742,0.002049712,0.03631002,0.04455061,0.9110896,0.0000706743],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002195134,0.948673,0.03056747,0.004754213,0.0009655473,0.00003762072,0.00005736322,0.0001103249,0.0126392],"genre_scores_gemma":[0.02933627,0.9277439,0.02835216,0.002309392,0.001678429,0.0001346264,0.00009213636,0.00005582695,0.01029731],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002535547,"threshold_uncertainty_score":0.008482277,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05041354898717492,"score_gpt":0.2881713322937629,"score_spread":0.237757783306588,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}