{"id":"W3122018968","doi":"10.1038/s41433-021-01400-9","title":"Comment on: ‘A randomized masked pilot clinical trial to compare the efficacy of topical 1% voriconazole ophthalmic solution as monotherapy with combination therapy of topical 0.02% polyhexamethylene biguanide and 0.02% chlorhexidine in the treatment of Acanthamoeba keratitis’","year":2021,"lang":"en","type":"letter","venue":"Eye","topic":"Legionella and Acanthamoeba research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Medicine; Biguanide; Voriconazole; Randomized controlled trial; Clinical trial; Dermatology; Ophthalmology; Surgery; Internal medicine; Antifungal","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007170324,0.000977648,0.001832423,0.0006331517,0.002878564,0.002427998,0.002643734,0.04686932,0.006056488],"category_scores_gemma":[0.02255812,0.0009382018,0.001757666,0.000897044,0.00231411,0.002575582,0.0007991365,0.0254887,0.006996895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003751947,"about_ca_system_score_gemma":0.003744584,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008365341,"about_ca_topic_score_gemma":0.01186117,"domain_scores_codex":[0.9962365,0.001263405,0.000514315,0.0007045027,0.000813671,0.0004676242],"domain_scores_gemma":[0.9876772,0.008478882,0.0008062226,0.0003634301,0.001448962,0.001225389],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001084554,0.00009992849,0.001397164,0.0001291937,0.00007184946,0.001951807,0.0001372263,0.0001018484,0.0005079094,0.001401052,0.9846439,0.008473542],"study_design_scores_gemma":[0.002483113,0.001249755,0.009164098,0.0005930045,0.0003793869,0.003580074,0.0006641534,0.001675739,0.002175431,0.01154242,0.966175,0.0003177893],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.001945577,0.0009088721,0.0001800153,0.9725317,0.02162036,0.00006531883,0.0003793259,0.00008632057,0.002282462],"genre_scores_gemma":[0.004553796,0.0002950335,0.0002660768,0.9795125,0.01237554,0.00007321266,0.00006722935,0.00002236193,0.00283409],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.04686932,"threshold_uncertainty_score":0.03792071,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06956600519607899,"score_gpt":0.3643778573129629,"score_spread":0.2948118521168839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}