{"id":"W3122018968","doi":"10.1038/s41433-021-01400-9","title":"Comment on: ‘A randomized masked pilot clinical trial to compare the efficacy of topical 1% voriconazole ophthalmic solution as monotherapy with combination therapy of topical 0.02% polyhexamethylene biguanide and 0.02% chlorhexidine in the treatment of Acanthamoeba keratitis’","year":2021,"lang":"en","type":"letter","venue":"Eye","topic":"Legionella and Acanthamoeba research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Medicine; Biguanide; Voriconazole; Randomized controlled trial; Clinical trial; Dermatology; Ophthalmology; Surgery; Internal medicine; Antifungal","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007245258,0.0002937089,0.0009793168,0.00008006113,0.00006795645,0.00002370279,0.000346898,0.000249152,0.00003422152],"category_scores_gemma":[0.0001288108,0.0001574452,0.0002792808,0.0001422672,0.0004568634,0.000003489428,0.00005439539,0.0003850671,8.233778e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004450865,"about_ca_system_score_gemma":0.0001755719,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007941487,"about_ca_topic_score_gemma":0.00007439041,"domain_scores_codex":[0.9964803,0.00157419,0.0007979235,0.0004392081,0.0004560632,0.0002522453],"domain_scores_gemma":[0.9979402,0.0009799073,0.0003123299,0.0005972605,0.0001216632,0.00004868057],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8633956,0.01206882,0.009794624,0.000170705,0.002239497,0.0001776501,0.003027258,0.00005875226,0.0640687,0.001333908,0.02836936,0.01529513],"study_design_scores_gemma":[0.6669928,0.04515516,0.01933963,0.0002353294,0.0001552621,0.00002771923,0.0003046722,0.0001070554,0.1916833,0.0001680988,0.07527592,0.000555047],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8710114,0.000802753,0.00009375372,0.1257263,0.0001732462,0.002043078,0.00002509728,0.000002818333,0.0001215489],"genre_scores_gemma":[0.9760735,0.003776852,0.00008164773,0.01855498,0.0008139472,0.0002136099,0.0002697011,0.00002489533,0.000190845],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1964028,"threshold_uncertainty_score":0.6420428,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06956600519607899,"score_gpt":0.3643778573129629,"score_spread":0.2948118521168839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}