{"id":"W3122024590","doi":"","title":"Nonsense suppression rescues cell death and photoreceptor protein expression in CDH23 patient iPSC-derived retinal organoids","year":2019,"lang":"en","type":"article","venue":"Investigative Ophthalmology & Visual Science","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Nonsense; Retinal; Cell biology; Organoid; Neuroscience; Biology; Medicine; Ophthalmology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002944831,0.0004655093,0.0005279075,0.0005840734,0.0003962134,0.0007642923,0.0005064906,0.0007162601,0.003702406],"category_scores_gemma":[0.0002545697,0.0001998025,0.000517214,0.0002509661,0.0004385026,0.0002024784,0.0004326593,0.001340318,0.001938491],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003426185,"about_ca_system_score_gemma":0.0003163965,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001582689,"about_ca_topic_score_gemma":0.001944565,"domain_scores_codex":[0.9996203,0.00003302224,0.00006546479,0.00007780032,0.0001502182,0.00005319687],"domain_scores_gemma":[0.9996485,0.0001060096,0.00006151111,0.00006745239,0.00003935048,0.0000772494],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003574202,0.00002534339,0.0001385933,0.00002041945,0.00001019831,0.0005544598,0.00003902001,0.0001144842,0.9976395,0.0001874882,0.0001113086,0.001123339],"study_design_scores_gemma":[0.00001400256,0.00006124082,0.002234024,0.000008458477,0.00002779157,0.001217953,0.00007790267,0.001110556,0.990815,0.0000774553,0.004345907,0.000009523617],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9759163,0.001168663,0.01098947,0.0002995439,0.0002237954,0.0001287103,0.003787999,0.0007661715,0.006719225],"genre_scores_gemma":[0.980523,0.0007403733,0.003768536,0.0001010175,0.00001975829,0.00009457695,0.002038465,0.0002918653,0.01242241],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003702406,"threshold_uncertainty_score":0.01238579,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0134361537396608,"score_gpt":0.2733332777136329,"score_spread":0.2598971239739721,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}