{"id":"W3122051635","doi":"10.1007/s00262-021-02851-5","title":"Preexisting autoimmune disease and immune-related adverse events associated with anti-PD-1 cancer immunotherapy: a national case series from the Canadian Research Group of Rheumatology in Immuno-Oncology","year":2021,"lang":"en","type":"article","venue":"Cancer Immunology Immunotherapy","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":78,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; University of Ottawa; Western University; University of Alberta; University of Toronto; Dalhousie University; University of British Columbia; University of Calgary; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Medicine; Immunosuppression; Internal medicine; Psoriatic arthritis; Discontinuation; Context (archaeology); Rheumatology; Adverse effect; Cancer; Rheumatoid arthritis; Psoriasis; Polyarthritis; Arthritis; Oncology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004141566,0.00101561,0.0007412914,0.001605295,0.002627668,0.001248688,0.0009674283,0.002428846,0.003263969],"category_scores_gemma":[0.003094075,0.0006939651,0.001098596,0.001244059,0.001262423,0.001225241,0.001075194,0.001777198,0.0006707553],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001923042,"about_ca_system_score_gemma":0.001740724,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01031619,"about_ca_topic_score_gemma":0.01793523,"domain_scores_codex":[0.9993241,0.00006914447,0.0001022326,0.0001462011,0.000132669,0.0002256763],"domain_scores_gemma":[0.997665,0.0005747522,0.0005105027,0.0002233963,0.0002421762,0.0007842106],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"observational","study_design_scores_codex":[0.00005135991,0.00009425332,0.1316203,0.00003106592,0.00003468689,0.8639544,0.0002977604,0.00008381465,0.0004525853,0.0001549432,0.001050601,0.002174139],"study_design_scores_gemma":[0.000009318542,0.00004121151,0.03450933,0.00001586974,0.00002753457,0.9641033,0.0003257566,0.0001150589,0.0001207248,0.0000668436,0.0006529878,0.00001209759],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.982356,0.002834598,0.0008089062,0.001601444,0.0001363263,0.0001178254,0.00031646,0.0000438018,0.01178464],"genre_scores_gemma":[0.9965141,0.001057384,0.0004458133,0.0006694653,0.0003200611,0.0000156112,0.0002102552,0.00001524189,0.0007520662],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9896838,"threshold_uncertainty_score":0.02051228,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03504324545533205,"score_gpt":0.3368035687868914,"score_spread":0.3017603233315593,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}