{"id":"W3122068670","doi":"10.20944/preprints201908.0101.v1","title":"Bezafibrate Improves Mitochondrial Fission and Function in DNM1L Deficient Patient Cells","year":2019,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"DNM1L; Bezafibrate; Dynamin; Mitochondrial fission; Mitochondrion; Cell biology; Biology; Cytosol; Endocrinology; Biochemistry; Endocytosis; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000144167,0.00029634,0.0005598827,0.0002478255,0.0001788118,0.0002297364,0.0002029599,0.0004245943,0.001590906],"category_scores_gemma":[0.0002375515,0.00007517763,0.0002489169,0.0001142578,0.0001335376,0.0001751477,0.0002123185,0.0006223094,0.000312262],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001909746,"about_ca_system_score_gemma":0.0001357137,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006017115,"about_ca_topic_score_gemma":0.0007570195,"domain_scores_codex":[0.9999145,0.00001504339,0.00001649403,0.00001922681,0.00001842014,0.00001627554],"domain_scores_gemma":[0.9998904,0.00001914686,0.00002476763,0.00001115637,0.00001376285,0.00004068351],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004221448,0.0004281398,0.001034207,0.000192414,0.00004466472,0.0007715757,0.0000579545,0.0001627855,0.9744126,0.0001043035,0.0005283265,0.0180415],"study_design_scores_gemma":[0.001370895,0.008433135,0.02196788,0.00007135626,0.0001951093,0.005069928,0.0002151409,0.001872109,0.9417,0.0004427746,0.01862722,0.00003451363],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944128,0.002864977,0.0007216889,0.0003388057,0.00006516283,0.000025408,0.0005114996,0.0001280706,0.0009315677],"genre_scores_gemma":[0.9962186,0.0009817134,0.000806298,0.0001483428,0.00001555608,0.00001584049,0.0006119774,0.00002508892,0.001176524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001590906,"threshold_uncertainty_score":0.005322099,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0349680182163064,"score_gpt":0.2779882568266016,"score_spread":0.2430202386102952,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}