{"id":"W3122082701","doi":"10.3390/cancers13030411","title":"The lncRNA H19-Derived MicroRNA-675 Promotes Liver Necroptosis by Targeting FADD","year":2021,"lang":"en","type":"article","venue":"Cancers","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"","keywords":"Necroptosis; FADD; Death domain; microRNA; Cell biology; Cancer research; Caspase 8; RIPK1; Programmed cell death; Apoptosis; Biology; Inflammation; Downregulation and upregulation; Chemistry; Caspase; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008356921,0.0001036544,0.00007633176,0.000006479781,0.0002312103,0.00004729936,0.000103253,0.00009433899,0.00005279302],"category_scores_gemma":[0.00003892337,0.00007963532,0.00007462196,0.00005942603,0.00005586379,0.000002551453,0.00006721819,0.00005891688,0.000006330416],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007080439,"about_ca_system_score_gemma":0.0001589362,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006440501,"about_ca_topic_score_gemma":0.00004065644,"domain_scores_codex":[0.9993083,0.00003771753,0.0001175281,0.0002520969,0.0000782502,0.0002060521],"domain_scores_gemma":[0.9995925,0.000009316783,0.00006174677,0.000196794,0.00008889944,0.00005073883],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001351183,0.000004064421,0.00004152649,0.000008423347,0.00003511215,0.00000231335,0.00005179789,0.00006225296,0.9770592,0.00002980476,0.01413386,0.008558157],"study_design_scores_gemma":[0.0001542169,0.00003281765,0.00009063472,0.000007840291,0.00001135883,0.000003612408,0.0001306389,0.0002307769,0.7610825,0.00002482428,0.2381313,0.0000994509],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9735695,0.02251912,0.002084364,0.0004220753,0.0004816489,0.0001635282,0.00002206399,0.00001600388,0.0007216634],"genre_scores_gemma":[0.9894155,0.004937042,0.0007666032,0.000285047,0.0002554426,0.00002268663,0.0002015429,0.00002358975,0.004092533],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2239974,"threshold_uncertainty_score":0.3247434,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006009386490645033,"score_gpt":0.210816252083205,"score_spread":0.20480686559256,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}