{"id":"W3122082701","doi":"10.3390/cancers13030411","title":"The lncRNA H19-Derived MicroRNA-675 Promotes Liver Necroptosis by Targeting FADD","year":2021,"lang":"en","type":"article","venue":"Cancers","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"","keywords":"Necroptosis; FADD; Death domain; microRNA; Cell biology; Cancer research; Caspase 8; RIPK1; Programmed cell death; Apoptosis; Biology; Inflammation; Downregulation and upregulation; Chemistry; Caspase; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001190981,0.0001891349,0.0001285973,0.0001588692,0.0001249887,0.0001917422,0.0001305468,0.0001149166,0.001270197],"category_scores_gemma":[0.00009682422,0.000104633,0.000236807,0.00007197562,0.0001619726,0.000105122,0.0001620637,0.0002209842,0.0003428186],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002284779,"about_ca_system_score_gemma":0.0002269771,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005318231,"about_ca_topic_score_gemma":0.000880277,"domain_scores_codex":[0.9999065,0.00001421367,0.00001141715,0.0000178178,0.00002229986,0.00002767603],"domain_scores_gemma":[0.9999367,0.00001005739,0.00002176368,0.000005489323,0.000007637621,0.00001834913],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002337063,0.00002752463,0.0009064871,0.00005823343,0.00001045465,0.0001426433,0.00002017438,0.00007207566,0.9940877,0.0001939042,0.0001062151,0.004140927],"study_design_scores_gemma":[0.0000365983,0.0005419716,0.009066134,0.000008555019,0.00004062096,0.0003911413,0.00004245088,0.001570913,0.9839714,0.00007028236,0.004253363,0.000006636364],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917191,0.00148322,0.003692094,0.000131685,0.00006843007,0.00002824302,0.0002154789,0.0001750803,0.002486591],"genre_scores_gemma":[0.9964764,0.000313575,0.001517381,0.00007991356,0.000009581431,0.00001319232,0.000189195,0.00001591535,0.001384789],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001270197,"threshold_uncertainty_score":0.004249275,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006009386490645033,"score_gpt":0.210816252083205,"score_spread":0.20480686559256,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}