{"id":"W3122091881","doi":"10.1016/j.cell.2020.12.024","title":"G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling","year":2021,"lang":"en","type":"article","venue":"Cell","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":150,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Horizon 2020; Vlaamse regering; KU Leuven; Fonds Wetenschappelijk Onderzoek; Austrian Science Fund; Max-Planck-Gesellschaft; Rijksuniversiteit Groningen; European Research Council; Ministerstwo Edukacji i Nauki; Deutsche Forschungsgemeinschaft; University of Bristol; Fundacja na rzecz Nauki Polskiej; Medizinische Universität Innsbruck; European Commission; Stichting TSC Fonds; European Molecular Biology Organization; Medical Research Council; Department of Health and Social Care; Academy of Medical Sciences; Wellcome Trust; Heart of England NHS Foundation Trust; Cancer Research UK; Ministère de l'Économie, de la Science et de l'Innovation - Québec; British Skin Foundation; Universität Innsbruck; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; Tuberous Sclerosis Association; Tuberous Sclerosis Alliance; Deutsches Krebsforschungszentrum","keywords":"mTORC1; Biology; RHEB; Cell biology; TSC2; Regulator; Stress granule; Zebrafish; Crosstalk; PI3K/AKT/mTOR pathway; Signal transduction; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001102082,0.0001193728,0.0001070821,0.00001272171,0.00009150136,0.00004903334,0.000181337,0.00008157051,0.0002341189],"category_scores_gemma":[0.00003508709,0.00009502182,0.0000520236,0.00006769703,0.00006249508,0.00000175123,0.0001724566,0.00007563713,0.00002412782],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009572203,"about_ca_system_score_gemma":0.00005304617,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001172209,"about_ca_topic_score_gemma":0.00001395629,"domain_scores_codex":[0.9991986,0.00006484536,0.0001164972,0.0003104173,0.0001038444,0.0002058518],"domain_scores_gemma":[0.9994268,0.00003414569,0.00003304464,0.0003528028,0.00007519674,0.00007801293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001504219,0.00001830294,0.0005068995,0.00001699601,0.00002283933,0.000006111391,0.0001461813,0.0002106625,0.986452,0.00001669243,0.01215229,0.0004359244],"study_design_scores_gemma":[0.0001871634,0.00004414609,0.0003568954,0.000008258943,0.00001357251,0.000007480258,0.000121284,0.0000237069,0.7497019,0.00004612972,0.2493723,0.0001171505],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883885,0.003571564,0.0007950905,0.0006815168,0.0002110295,0.0001218172,0.00002565109,0.0000135033,0.006191357],"genre_scores_gemma":[0.9927083,0.00006364941,0.0007168302,0.001978427,0.0003648281,0.00001580345,0.00003604404,0.00002560237,0.004090549],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.23722,"threshold_uncertainty_score":0.3874877,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01725092436568859,"score_gpt":0.2573578287233377,"score_spread":0.2401069043576491,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}