{"id":"W3122091881","doi":"10.1016/j.cell.2020.12.024","title":"G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling","year":2021,"lang":"en","type":"article","venue":"Cell","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":150,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Horizon 2020; Vlaamse regering; KU Leuven; Fonds Wetenschappelijk Onderzoek; Austrian Science Fund; Max-Planck-Gesellschaft; Rijksuniversiteit Groningen; European Research Council; Ministerstwo Edukacji i Nauki; Deutsche Forschungsgemeinschaft; University of Bristol; Fundacja na rzecz Nauki Polskiej; Medizinische Universität Innsbruck; European Commission; Stichting TSC Fonds; European Molecular Biology Organization; Medical Research Council; Department of Health and Social Care; Academy of Medical Sciences; Wellcome Trust; Heart of England NHS Foundation Trust; Cancer Research UK; Ministère de l'Économie, de la Science et de l'Innovation - Québec; British Skin Foundation; Universität Innsbruck; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; Tuberous Sclerosis Association; Tuberous Sclerosis Alliance; Deutsches Krebsforschungszentrum","keywords":"mTORC1; Biology; RHEB; Cell biology; TSC2; Regulator; Stress granule; Zebrafish; Crosstalk; PI3K/AKT/mTOR pathway; Signal transduction; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001861297,0.0006273264,0.000423406,0.0006787595,0.000612107,0.0006612064,0.0005245549,0.0005742153,0.003620649],"category_scores_gemma":[0.0002339486,0.0003173732,0.0004107814,0.0004777227,0.0006226621,0.0003062118,0.0006774302,0.001283434,0.001997643],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001478108,"about_ca_system_score_gemma":0.0008182283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003742145,"about_ca_topic_score_gemma":0.007978501,"domain_scores_codex":[0.9996839,0.00003412338,0.00002000451,0.00005976755,0.00009653452,0.0001057798],"domain_scores_gemma":[0.9998766,0.00001245721,0.00002397,0.00002340554,0.00001499489,0.00004858512],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004183383,0.00004914802,0.000333016,0.0000711786,0.00002417258,0.0001648214,0.00002017643,0.0003287469,0.9921871,0.001207842,0.002101604,0.003093897],"study_design_scores_gemma":[0.0000487369,0.00006613538,0.002501704,0.000005111221,0.00001422539,0.0001797328,0.00004632814,0.0009934315,0.9878166,0.0002907649,0.008029666,0.000007482248],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9575604,0.005807559,0.009592932,0.003613383,0.0006791216,0.000102108,0.003961699,0.002293153,0.01638967],"genre_scores_gemma":[0.9859972,0.001000391,0.002503304,0.000552797,0.00003354861,0.00006207691,0.001116125,0.0001856345,0.008548887],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003742145,"threshold_uncertainty_score":0.01211232,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01725092436568859,"score_gpt":0.2573578287233377,"score_spread":0.2401069043576491,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}