{"id":"W3122132687","doi":"10.1007/s13555-021-00490-3","title":"Long-Term Safety and Efficacy of Risankizumab in Patients with Moderate-to-Severe Chronic Plaque Psoriasis: Results from a Phase 2 Open-Label Extension Trial","year":2021,"lang":"en","type":"article","venue":"Dermatology and Therapy","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research","funders":"","keywords":"Medicine; Psoriasis; Psoriasis Area and Severity Index; Adverse effect; Internal medicine; Ustekinumab; Plaque psoriasis; Open label; Randomized controlled trial; Clinical trial; Dermatology; Gastroenterology; Disease; Adalimumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001027079,0.0002519523,0.0006716722,0.00009790856,0.0001629339,0.00002005092,0.0001454741,0.0003375305,0.00007409655],"category_scores_gemma":[0.00003345767,0.0001967862,0.00002952314,0.0001471854,0.0001339871,0.0001194057,0.00009639097,0.0001605423,0.00001107051],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002463602,"about_ca_system_score_gemma":0.0001292645,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007826366,"about_ca_topic_score_gemma":0.0001663976,"domain_scores_codex":[0.9982187,0.0004537687,0.0004565057,0.0005531131,0.00003712715,0.0002808558],"domain_scores_gemma":[0.9990478,0.0003357235,0.0001632965,0.0003425874,0.00006943224,0.00004122831],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8243502,0.004195313,0.01998313,0.00001535717,0.0009350525,0.0001895435,0.001290913,0.00000667159,0.003777144,0.0001053107,0.0001300325,0.1450214],"study_design_scores_gemma":[0.7636113,0.002167144,0.2079582,0.0001440493,0.0001211025,0.0001193035,0.00003800021,0.000008326985,0.02468554,0.0001031435,0.0007094568,0.0003344467],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888908,0.009248866,0.00003520509,0.0002384579,0.0003046637,0.0008420582,0.0003709421,0.00001809643,0.00005093694],"genre_scores_gemma":[0.9959901,0.002400891,0.00008551885,0.0001490531,0.00002009978,0.00003639155,0.001240773,0.00001730916,0.00005984865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1879751,"threshold_uncertainty_score":0.8024707,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02387485861242551,"score_gpt":0.2783510814867329,"score_spread":0.2544762228743074,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}