{"id":"W3122139996","doi":"10.3389/fneur.2020.628014","title":"Impaired Ganglion Cell Function Objectively Assessed by the Photopic Negative Response in Affected and Asymptomatic Members From Brazilian Families With Leber's Hereditary Optic Neuropathy","year":2021,"lang":"en","type":"article","venue":"Frontiers in Neurology","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Photopic vision; Ophthalmology; Electroretinography; Erg; Asymptomatic; Medicine; Ganglion; Visual field; Leber's hereditary optic neuropathy; Retinal ganglion cell; Audiology; Retinal; Optic neuropathy; Internal medicine; Optic nerve; Anatomy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003291838,0.0004752159,0.0002250854,0.0005897875,0.0003697928,0.0003048437,0.0001879431,0.0002700468,0.001759634],"category_scores_gemma":[0.001702879,0.0002157327,0.0001667776,0.0002440121,0.0004154707,0.0001647579,0.0003715085,0.0001621982,0.0001594916],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002188438,"about_ca_system_score_gemma":0.0001558099,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01009242,"about_ca_topic_score_gemma":0.01014083,"domain_scores_codex":[0.9998158,0.00004997931,0.00001946825,0.00004748519,0.00003121362,0.00003618341],"domain_scores_gemma":[0.9995389,0.00009741429,0.0002084058,0.0000275939,0.00004851482,0.00007927237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001741483,0.00005857749,0.9914604,0.00002491294,0.0000261049,0.001355908,0.001099991,0.00002298965,0.003137723,0.00002161758,0.00006396259,0.002553693],"study_design_scores_gemma":[0.00000716099,0.0001705548,0.9958056,0.00001247572,0.00002547663,0.002899177,0.0007503061,0.00005883988,0.0001245764,0.0000186766,0.0001239893,0.000003121652],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9997448,0.0000615211,0.00002164957,0.000006591158,6.562233e-7,0.00000321957,0.00003068546,0.000001107533,0.0001297189],"genre_scores_gemma":[0.9997643,0.00005834148,0.00003829741,0.000008270502,0.000001069762,0.000003612811,0.00005600707,6.328366e-7,0.00006947019],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01009242,"threshold_uncertainty_score":0.02006733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002553053995139374,"score_gpt":0.1825936445042167,"score_spread":0.1800405905090773,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}