{"id":"W3122139996","doi":"10.3389/fneur.2020.628014","title":"Impaired Ganglion Cell Function Objectively Assessed by the Photopic Negative Response in Affected and Asymptomatic Members From Brazilian Families With Leber's Hereditary Optic Neuropathy","year":2021,"lang":"en","type":"article","venue":"Frontiers in Neurology","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Photopic vision; Ophthalmology; Electroretinography; Erg; Asymptomatic; Medicine; Ganglion; Visual field; Leber's hereditary optic neuropathy; Retinal ganglion cell; Audiology; Retinal; Optic neuropathy; Internal medicine; Optic nerve; Anatomy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001653767,0.0002020204,0.0002238386,0.00009634009,0.00006510072,0.00002440523,0.0001178334,0.0001604923,0.000008612111],"category_scores_gemma":[0.0001864368,0.0001664499,0.00003354513,0.000288531,0.000174474,0.0000140137,0.0000732215,0.0002193643,8.448177e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001652608,"about_ca_system_score_gemma":0.0001243295,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001179422,"about_ca_topic_score_gemma":0.0003949452,"domain_scores_codex":[0.9980943,0.0008482711,0.0001966869,0.0004952133,0.0001078781,0.0002577182],"domain_scores_gemma":[0.9994943,0.0001224203,0.0000819065,0.0002155849,0.00003976135,0.00004608784],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02126708,0.0004470265,0.4939466,0.00006821427,0.0001743931,0.0009181103,0.001915114,0.000559271,0.464922,0.000003338681,0.01387449,0.001904321],"study_design_scores_gemma":[0.003409845,0.001671698,0.9611572,0.00001782963,0.00003816839,0.00005420848,0.002537561,0.001329542,0.02867059,0.0002319884,0.0005842551,0.0002970824],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970779,0.001007048,0.0003906294,0.0004913316,0.0004035549,0.0003052053,0.00001155993,0.00001421052,0.0002986031],"genre_scores_gemma":[0.9982909,0.0001707746,0.0004493919,0.0007955189,0.00002468883,0.000050044,0.0001039685,0.00002377149,0.00009096857],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4672106,"threshold_uncertainty_score":0.6787628,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002553053995139374,"score_gpt":0.1825936445042167,"score_spread":0.1800405905090773,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}