{"id":"W3122172605","doi":"10.3389/fped.2020.618918","title":"Advanced Understanding of Monogenic Inflammatory Bowel Disease","year":2021,"lang":"en","type":"review","venue":"Frontiers in Pediatrics","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; SickKids Foundation; Hospital for Sick Children","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Institutes of Health Research; Leona M. and Harry B. Helmsley Charitable Trust","keywords":"Medicine; Inflammatory bowel disease; Ulcerative colitis; Disease; Crohn's disease; Genetic testing; Inflammatory Bowel Diseases; Immunology; Differential diagnosis; Pathogenesis; Bioinformatics; Internal medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008760426,0.0008072508,0.001133982,0.002538656,0.0003780608,0.001214897,0.0008386616,0.001301438,0.002785429],"category_scores_gemma":[0.001624426,0.0002309507,0.0005378374,0.002146042,0.000748352,0.002334687,0.000931814,0.002380694,0.001496021],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009030931,"about_ca_system_score_gemma":0.001509493,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001249313,"about_ca_topic_score_gemma":0.00101406,"domain_scores_codex":[0.9995399,0.0001031339,0.00009107224,0.00009506054,0.000129794,0.00004119737],"domain_scores_gemma":[0.999267,0.0003163862,0.00009027107,0.00003044779,0.000234553,0.00006126983],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001381997,0.00007196421,0.001942192,0.01793005,0.000159722,0.001562615,0.0006546592,0.0004708615,0.004372091,0.01514292,0.06442407,0.8931307],"study_design_scores_gemma":[0.00001201818,0.0001031699,0.00363984,0.004157089,0.0001269932,0.006059293,0.0002158496,0.0001801666,0.000530679,0.007302695,0.9776375,0.00003463787],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004393054,0.9939593,0.0007719413,0.001816081,0.001016189,0.000006793818,0.00004398636,0.00001883114,0.001927632],"genre_scores_gemma":[0.003854231,0.9899141,0.001258045,0.001637121,0.002374292,0.00001648864,0.0001157763,0.000004825391,0.0008251289],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002785429,"threshold_uncertainty_score":0.009318113,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02073018622695691,"score_gpt":0.2612454047690746,"score_spread":0.2405152185421177,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}