{"id":"W3122203814","doi":"10.1016/j.vaccine.2021.01.044","title":"Recombinant SARS-CoV-2 RBD with a built in T helper epitope induces strong neutralization antibody response","year":2021,"lang":"en","type":"article","venue":"Vaccine","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"Artron Bioresearch (Canada)","funders":"","keywords":"Immunogenicity; Virology; Antigenicity; Humoral immunity; Toxoid; Immunity; Epitope; Neutralizing antibody; Antibody; Immune system; Biology; Cellular immunity; Neutralization; Recombinant DNA; Antigen; Immunology; Vaccination; Tetanus; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003054503,0.0007242341,0.0003844187,0.000320653,0.0001777702,0.0003314451,0.0002117648,0.0005143385,0.001722323],"category_scores_gemma":[0.0002374242,0.0002110311,0.0003674111,0.0001337665,0.0002359096,0.0001916675,0.0003411498,0.001451746,0.0007125332],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003195714,"about_ca_system_score_gemma":0.0002262205,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000488612,"about_ca_topic_score_gemma":0.0004849175,"domain_scores_codex":[0.9996731,0.00005867701,0.00002222149,0.00004773912,0.00005566002,0.0001426423],"domain_scores_gemma":[0.9998316,0.00006250219,0.00001846097,0.00002195779,0.0000221939,0.00004328818],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002645419,0.0001790552,0.0002866084,0.00003205131,0.000009592212,0.00007395408,0.00002159296,0.0001017794,0.9978355,0.00007304428,0.0001440002,0.0009782345],"study_design_scores_gemma":[0.0002476477,0.00272929,0.006921235,0.00001076517,0.00004611912,0.0006618904,0.00008807393,0.00207689,0.9835277,0.00012486,0.003555162,0.00001046412],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948794,0.0004795194,0.001991448,0.0001321681,0.0001572322,0.00008041662,0.000301084,0.00008741163,0.001891329],"genre_scores_gemma":[0.9958688,0.0001873881,0.0009317434,0.0001568594,0.00005077085,0.00003121378,0.0007438608,0.00001939603,0.002009944],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001722323,"threshold_uncertainty_score":0.005761802,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05014774602933392,"score_gpt":0.3745375700708186,"score_spread":0.3243898240414846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}