{"id":"W3122205112","doi":"10.1038/s41574-020-00459-w","title":"Targeting lipid GPCRs to treat type 2 diabetes mellitus — progress and challenges","year":2021,"lang":"en","type":"review","venue":"Nature Reviews Endocrinology","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":99,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Free fatty acid receptor 1; G protein-coupled receptor; Medicine; Type 2 Diabetes Mellitus; Receptor; Incretin; Type 2 diabetes; Insulin; Glucose homeostasis; Diabetes mellitus; GPR120; Pharmacology; Bioinformatics; Endocrinology; Internal medicine; Insulin resistance; Biology; Agonist","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003324349,0.000786178,0.005596524,0.0003691576,0.00008153916,0.00003077052,0.0001992334,0.0009500417,0.0002177615],"category_scores_gemma":[0.002044824,0.0005312691,0.0005419764,0.0005762088,0.0001273097,0.0000423086,0.000212232,0.001500984,0.0003078298],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001135066,"about_ca_system_score_gemma":0.0002030282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001234006,"about_ca_topic_score_gemma":6.618386e-7,"domain_scores_codex":[0.9963113,0.0006176309,0.0009555962,0.001060363,0.0002190776,0.0008360535],"domain_scores_gemma":[0.9978451,0.0004657449,0.0003644095,0.0007539088,0.0001964233,0.0003744432],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000006164625,0.00006427376,0.00003599242,0.05355545,0.0002170289,0.00007936102,0.00002358236,8.315689e-9,0.00000224861,0.0004659832,0.008392985,0.9371569],"study_design_scores_gemma":[0.0002967696,0.0003172273,0.000009077989,0.023095,0.002247911,0.0002629404,0.00001583168,3.511022e-7,0.0000120497,0.000005472561,0.973334,0.000403414],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00001895593,0.9929529,4.388682e-7,0.001315302,0.001131177,0.002106741,0.0000145391,0.0001234446,0.002336454],"genre_scores_gemma":[0.0000030862,0.9950716,0.001220784,0.0009392298,0.001124001,0.0005072502,0.0002915466,0.00008946972,0.0007529583],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.964941,"threshold_uncertainty_score":0.9997139,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06410029733960587,"score_gpt":0.3580117363681736,"score_spread":0.2939114390285678,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}