{"id":"W3122241329","doi":"10.1002/etc.4985","title":"Toxicity Screening of Bisphenol A Replacement Compounds: Cytotoxicity and mRNA Expression in Primary Hepatocytes of Chicken and Double-Crested Cormorant","year":2021,"lang":"en","type":"article","venue":"Environmental Toxicology and Chemistry","topic":"Effects and risks of endocrine disrupting chemicals","field":"Environmental Science","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Environment and Climate Change Canada","funders":"","keywords":"Cormorant; Gene expression; Gene; Cytotoxicity; Viability assay; Cytochrome P450; Bisphenol A; Biology; Estrogen; Chemistry; Biochemistry; Molecular biology; In vitro; Metabolism; Genetics; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001002352,0.0003144967,0.0002167378,0.0002577999,0.0001812794,0.0002275707,0.0001119584,0.0002262801,0.0008110455],"category_scores_gemma":[0.00008184717,0.0001524872,0.0002590323,0.0001517965,0.0002251815,0.0001110146,0.000123957,0.000217276,0.0002431394],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002860457,"about_ca_system_score_gemma":0.0001717339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003351975,"about_ca_topic_score_gemma":0.006265549,"domain_scores_codex":[0.9998716,0.00001420615,0.00001041051,0.00005209236,0.00003093667,0.0000207114],"domain_scores_gemma":[0.999882,0.00002160347,0.00001926785,0.00001303462,0.00004152578,0.00002256598],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007776908,0.000007826389,0.0005945226,0.00001591413,0.00000388736,0.00001970831,0.00001227355,0.00002187609,0.9990323,0.000005780258,0.000005966974,0.0002021656],"study_design_scores_gemma":[0.00001213661,0.0006198061,0.04320376,0.000004028921,0.00004027897,0.0001546709,0.0001523542,0.0004457508,0.9544509,0.00001266021,0.0008972783,0.00000630971],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966396,0.0005712297,0.001318393,0.00002935325,0.00001855463,0.00002995029,0.0007815345,0.00002356169,0.000587853],"genre_scores_gemma":[0.9875367,0.0007064713,0.003393097,0.00009485885,0.000009508904,0.0001089362,0.001865447,0.00002371942,0.006261139],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003351975,"threshold_uncertainty_score":0.006664932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008580566169095841,"score_gpt":0.2594676264980061,"score_spread":0.2508870603289103,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}