{"id":"W3122290535","doi":"10.1016/j.cell.2021.01.035","title":"Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection","year":2021,"lang":"en","type":"article","venue":"Cell","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":205,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Infection and Immunity; Agence Nationale de la Recherche; Fondation Bettencourt Schueller; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Institutes of Health; University of Southampton; Universiteit van Amsterdam; Bill and Melinda Gates Foundation; ZonMw; Amsterdam University Medical Centers; National Institute of Allergy and Infectious Diseases; Health~Holland","keywords":"Biology; Virology; Pandemic; Immunity; Immunization; Coronavirus; Transmission (telecommunications); Antibody; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Viral replication; Immune system; Coronavirus disease 2019 (COVID-19); Immunology; Virus; Disease; Infectious disease (medical specialty); Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001076168,0.0003340569,0.0002537871,0.0001745162,0.0001293493,0.0001726487,0.0001901104,0.0004984908,0.0006578872],"category_scores_gemma":[0.0001230447,0.00007398355,0.0001721579,0.00004259999,0.0001705718,0.0001725995,0.0001742171,0.000367575,0.0001469546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001699264,"about_ca_system_score_gemma":0.0001887811,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004735308,"about_ca_topic_score_gemma":0.000772008,"domain_scores_codex":[0.9999419,0.000008326329,0.000003446423,0.00001261538,0.00001502195,0.00001864712],"domain_scores_gemma":[0.9999601,0.000005922699,0.000007510284,0.000004601688,0.0000101018,0.00001181041],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001286584,0.0001344475,0.0002035051,0.00003074425,0.000007522551,0.00004505931,0.00001753633,0.0001441786,0.9959032,0.0001103448,0.0001229534,0.003151782],"study_design_scores_gemma":[0.0001400858,0.004733638,0.006216981,0.00002194037,0.00005990585,0.0005681157,0.00007855036,0.005988178,0.9743696,0.000282902,0.007526135,0.00001400893],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960455,0.0006593043,0.002227281,0.0001775827,0.00006052508,0.00003041825,0.00005662844,0.00005855471,0.000684028],"genre_scores_gemma":[0.9948231,0.0004218627,0.002339536,0.0001698707,0.00002050908,0.000036905,0.0002127673,0.000009746565,0.001965661],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006578872,"threshold_uncertainty_score":0.002200842,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03932194075551897,"score_gpt":0.3332203965273078,"score_spread":0.2938984557717889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}