{"id":"W3122290535","doi":"10.1016/j.cell.2021.01.035","title":"Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection","year":2021,"lang":"en","type":"article","venue":"Cell","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":205,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Infection and Immunity; Agence Nationale de la Recherche; Fondation Bettencourt Schueller; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Institutes of Health; University of Southampton; Universiteit van Amsterdam; Bill and Melinda Gates Foundation; ZonMw; Amsterdam University Medical Centers; National Institute of Allergy and Infectious Diseases; Health~Holland","keywords":"Biology; Virology; Pandemic; Immunity; Immunization; Coronavirus; Transmission (telecommunications); Antibody; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Viral replication; Immune system; Coronavirus disease 2019 (COVID-19); Immunology; Virus; Disease; Infectious disease (medical specialty); Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001659603,0.0001842964,0.0003018446,0.00009850311,0.00009430222,0.0000611593,0.00009248174,0.000101232,0.00008134055],"category_scores_gemma":[0.0001087884,0.0001676358,0.0001224013,0.0003794183,0.00003019964,0.0001024526,0.0001240175,0.0003247808,0.0008248702],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001405357,"about_ca_system_score_gemma":0.0002154124,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001930492,"about_ca_topic_score_gemma":0.0002849862,"domain_scores_codex":[0.9983936,0.00009954802,0.0002696975,0.0004484123,0.0003843826,0.0004043908],"domain_scores_gemma":[0.9991286,0.00006717747,0.00005872177,0.0005049775,0.0001893309,0.00005118696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002021947,0.0004288811,0.02329038,0.0001062304,0.00003516311,0.0003536212,0.0001652592,5.711344e-7,0.9723903,0.00001763668,0.000993105,0.002016666],"study_design_scores_gemma":[0.002716523,0.0001931897,0.01016809,0.00007649629,0.00004671742,0.00003066611,0.00003476811,0.0004899452,0.9148884,0.0003351226,0.07086078,0.0001593462],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900766,0.0007814507,0.0001577464,0.0005187298,0.0002437583,0.0004970414,0.000005280956,0.0001647729,0.00755461],"genre_scores_gemma":[0.9851096,0.00001373782,0.0003482048,0.01389049,0.0003809945,0.00007276962,0.00001514963,0.00003763794,0.0001313651],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06986768,"threshold_uncertainty_score":0.9999531,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03932194075551897,"score_gpt":0.3332203965273078,"score_spread":0.2938984557717889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}