{"id":"W3122352349","doi":"10.1101/2021.01.26.21250318","title":"Epigenetic impairment and blunted transcriptional response to <i>Mycobacterium tuberculosis</i> of alveolar macrophages from persons living with HIV","year":2021,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Pneumocystis jirovecii pneumonia detection and treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University and Génome Québec Innovation Centre; Centre Hospitalier Universitaire Sainte-Justine; McGill University; McGill University Health Centre","funders":"National Institutes of Health; McGill University Health Centre; Western Canada Research Grid; Compute Canada; Génome Québec; Ministerio de Ciencia e Innovación; Styrelsen för Internationellt Utvecklingssamarbete","keywords":"Epigenetics; Tuberculosis; Immunology; Chromatin; Medicine; Immune system; Mycobacterium tuberculosis; Human immunodeficiency virus (HIV); Innate immune system; Disease; Transcriptome; Biology; Gene; Internal medicine; Gene expression; Genetics; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001425974,0.0001545031,0.0001798971,0.0001977738,0.0002456989,0.0002839083,0.0001057729,0.0002207305,0.001747285],"category_scores_gemma":[0.0001644706,0.0001164165,0.0001298509,0.0001015528,0.0002208252,0.00008761697,0.0002373371,0.0002749955,0.0002695948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008724188,"about_ca_system_score_gemma":0.00008005716,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000671988,"about_ca_topic_score_gemma":0.0005597346,"domain_scores_codex":[0.9998704,0.00001887495,0.00001393326,0.00003998461,0.00001957092,0.0000371754],"domain_scores_gemma":[0.9999212,0.00001350206,0.00001950435,0.0000106547,0.00001487725,0.00002024253],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009210249,0.0000729682,0.02492145,0.00006080608,0.00001720906,0.0002271647,0.0001923003,0.00002629143,0.9705552,0.00003538014,0.00009993718,0.002870029],"study_design_scores_gemma":[0.00004771734,0.001447803,0.7644834,0.00002424228,0.00005691211,0.001700536,0.0009601117,0.000447094,0.2288933,0.0001149714,0.001812618,0.0000112717],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990875,0.0002039059,0.0001819845,0.0000299888,0.000005443453,0.000009144663,0.0002467754,0.000005377567,0.0002298884],"genre_scores_gemma":[0.9988931,0.00009633772,0.0001441386,0.00004837725,0.000008450642,0.00001592136,0.0003555579,0.000002550696,0.000435761],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001747285,"threshold_uncertainty_score":0.005845249,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009239163675623985,"score_gpt":0.2364547731309932,"score_spread":0.2272156094553692,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}