{"id":"W3122496044","doi":"10.20944/preprints201801.0179.v1","title":"Proteostasis in Huntington’s Disease: Disease Mechanisms and Therapeutic Opportunities","year":2018,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Ontario Ministry of Economic Development and Innovation; Novartis Pharma; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Wellcome Trust; Ministero dello Sviluppo Economico; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; Diamond Light Source; Ontario Genomics; Pfizer","keywords":"Proteostasis; Proteasome; Autophagy; Protein aggregation; Biology; Disease; Ubiquitin; Cell biology; Huntington's disease; Protein folding; Neuroscience; Medicine; Biochemistry; Apoptosis; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00041013,0.0004873326,0.0009019034,0.0006919341,0.0002279207,0.0009299616,0.000337509,0.0008902297,0.002652855],"category_scores_gemma":[0.0002425358,0.0001089102,0.0003594891,0.0004435659,0.0005655352,0.0006092605,0.0005793493,0.0009773672,0.00097046],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004883913,"about_ca_system_score_gemma":0.0004506894,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003500673,"about_ca_topic_score_gemma":0.0005391669,"domain_scores_codex":[0.9999062,0.00002237915,0.00001010009,0.00001828196,0.00002764426,0.00001534609],"domain_scores_gemma":[0.9999267,0.00001995296,0.00001519681,0.000005158529,0.00001908279,0.00001402228],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0008631137,0.0002514294,0.001260496,0.01167126,0.0002497947,0.002709292,0.0004537816,0.001151298,0.04553121,0.03138251,0.03357933,0.8708966],"study_design_scores_gemma":[0.0002088367,0.001047019,0.006308474,0.0049039,0.0004150629,0.01213834,0.0004090151,0.001411167,0.02693174,0.06236135,0.8837698,0.00009529164],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.007224314,0.982608,0.002320763,0.002093149,0.0004862715,0.00002037297,0.0001196106,0.00009160431,0.005035956],"genre_scores_gemma":[0.05920507,0.9314558,0.002892455,0.0006885486,0.001159947,0.00005156049,0.000325051,0.00003165361,0.004190006],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002652855,"threshold_uncertainty_score":0.008874655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2873805630289269,"score_gpt":0.3654552763340343,"score_spread":0.07807471330510735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}