{"id":"W3122558395","doi":"10.1200/jco.2021.39.3_suppl.61","title":"Tissue and plasma tumor mutation burden (TMB) as predictive biomarkers in the CO.26 trial of durvalumab + tremelimumab (D+T) versus best supportive care (BSC) in metastatic colorectal cancer (mCRC).","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Ottawa Hospital; BC Cancer Agency; University Health Network; Queen's University; Genome British Columbia","funders":"","keywords":"Medicine; Colorectal cancer; Internal medicine; Microsatellite instability; Population; Oncology; Pembrolizumab; Durvalumab; Gastroenterology; Oxaliplatin; Immunotherapy; Hazard ratio; Cancer; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003889495,0.0007695639,0.001077385,0.0002609188,0.0001835812,0.0008002262,0.0004434186,0.0008110915,0.001838065],"category_scores_gemma":[0.002777082,0.0003535638,0.0007972631,0.0003033833,0.0005658031,0.000574157,0.0003766739,0.001642228,0.0003190776],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007205186,"about_ca_system_score_gemma":0.0007219769,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003216515,"about_ca_topic_score_gemma":0.0009905688,"domain_scores_codex":[0.9986926,0.0008634925,0.00004798262,0.0002105999,0.00008122944,0.0001042049],"domain_scores_gemma":[0.9974866,0.0009715158,0.0007674351,0.0001159174,0.000113162,0.0005453333],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9510006,0.001693188,0.0191589,0.0002647537,0.0008415623,0.00005252885,0.00007497413,0.001049105,0.007501247,0.000114834,0.00100744,0.01724092],"study_design_scores_gemma":[0.4256619,0.3817421,0.1563409,0.0001589185,0.006062084,0.000534681,0.0001244593,0.009271375,0.01127076,0.0007345255,0.007986536,0.000111769],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995321,0.002499735,0.0002785774,0.0002809377,0.00006729977,0.0002673098,0.0003716989,0.00001349975,0.0008999798],"genre_scores_gemma":[0.997001,0.0004049536,0.0004678001,0.0001595594,0.00007708149,0.0003895684,0.0006562363,0.000009428863,0.0008342891],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003889495,"threshold_uncertainty_score":0.02056992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09661752577408858,"score_gpt":0.478105301557651,"score_spread":0.3814877757835624,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}