{"id":"W3122646042","doi":"10.1242/jcs.244012","title":"The p.E152K-STIM1 mutation deregulates Ca2+ signaling contributing to chronic pancreatitis","year":2021,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network; Western University","funders":"Ministerio de Economía y Competitividad; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Institut National de la Santé et de la Recherche Médicale; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Alliance Nationale pour les Sciences de la Vie et de la Santé","keywords":"Endoplasmic reticulum; SERCA; Biology; STIM1; Cell biology; Intracellular; Calcium signaling; Crosstalk; HEK 293 cells; Pancreatitis; Signal transduction; Endocrinology; Internal medicine; ATPase; Biochemistry; Receptor; Enzyme; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001718958,0.0004835376,0.000242258,0.0004229429,0.000253843,0.0002651529,0.0001632982,0.0005160531,0.002289627],"category_scores_gemma":[0.0003624534,0.0001101118,0.0003065325,0.0003366447,0.0003691005,0.0001379028,0.0003754545,0.0003211854,0.0003279143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00020318,"about_ca_system_score_gemma":0.0001303765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004761234,"about_ca_topic_score_gemma":0.0004614118,"domain_scores_codex":[0.9998519,0.00002910631,0.00003051761,0.00003518486,0.00002607324,0.00002709095],"domain_scores_gemma":[0.9998222,0.00004542451,0.00006254805,0.0000158844,0.00001239108,0.0000415334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001946234,0.0002964162,0.09228008,0.00009092445,0.0001634305,0.06957734,0.0005417221,0.0006584347,0.8221002,0.0009187419,0.0007215986,0.01070485],"study_design_scores_gemma":[0.0002089439,0.00127127,0.5246708,0.00009104894,0.0002880435,0.236435,0.000811703,0.004357142,0.2202801,0.001643118,0.009870996,0.00007184357],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998872,0.0001193351,0.0003093719,0.00006355339,0.00001172298,0.000008934657,0.000130674,0.000009914468,0.0004745263],"genre_scores_gemma":[0.9992754,0.00007821984,0.0001868883,0.00003652923,0.000008116758,0.000003906288,0.00008608928,0.000006481676,0.0003183847],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002289627,"threshold_uncertainty_score":0.007659554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01389621932728263,"score_gpt":0.2627712382083198,"score_spread":0.2488750188810372,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}