{"id":"W3122660020","doi":"10.1016/j.stem.2020.12.017","title":"Selective antisense oligonucleotide inhibition of human IRF4 prevents malignant myeloma regeneration via cell cycle disruption","year":2021,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; NIH Clinical Center; National Cancer Institute; National Institutes of Health; Moores Cancer Center, UC San Diego Health; National Aeronautics and Space Administration; Georgia Clinical and Translational Science Alliance; Ionis Pharmaceuticals; University of California, San Diego; University of Toronto","keywords":"IRF4; Cancer research; Multiple myeloma; Progenitor cell; Biology; Stem cell; Haematopoiesis; Immunology; Cell biology; Transcription factor; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001973171,0.000262115,0.0004118597,0.0001499977,0.000206745,0.00003193918,0.00006079484,0.0001514278,0.0001801585],"category_scores_gemma":[0.000007771377,0.0002482517,0.0001879405,0.0003521642,0.00005701393,0.0001513441,0.0000861342,0.0001959561,0.0001555525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002303628,"about_ca_system_score_gemma":0.0001391074,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001173756,"about_ca_topic_score_gemma":0.00004151816,"domain_scores_codex":[0.9977056,0.0002445919,0.0005018537,0.0005479604,0.0005177128,0.000482307],"domain_scores_gemma":[0.9986743,0.0000464857,0.0002463684,0.0004542959,0.0003118883,0.000266665],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001676876,0.001447355,0.006123978,0.000718126,0.00004369547,0.0004319893,0.0003741912,0.00004076609,0.9870332,0.00001447283,0.0003586477,0.003245875],"study_design_scores_gemma":[0.003740475,0.0006015944,0.02254665,0.0001763006,0.0001230811,0.00003445877,0.0002108232,0.0009213749,0.9712847,0.00007623726,0.00008838979,0.0001958791],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846566,0.0006309602,0.0005483436,0.00004790808,0.0001070859,0.0008242293,0.00004295085,0.00005457108,0.01308733],"genre_scores_gemma":[0.988943,0.0002229291,0.0005786432,0.00003445349,0.0001177451,0.00004185439,0.0005967118,0.00005318117,0.009411464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01642268,"threshold_uncertainty_score":0.999997,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01718121206281325,"score_gpt":0.2732852702099089,"score_spread":0.2561040581470957,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}