{"id":"W3122660020","doi":"10.1016/j.stem.2020.12.017","title":"Selective antisense oligonucleotide inhibition of human IRF4 prevents malignant myeloma regeneration via cell cycle disruption","year":2021,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; NIH Clinical Center; National Cancer Institute; National Institutes of Health; Moores Cancer Center, UC San Diego Health; National Aeronautics and Space Administration; Georgia Clinical and Translational Science Alliance; Ionis Pharmaceuticals; University of California, San Diego; University of Toronto","keywords":"IRF4; Cancer research; Multiple myeloma; Progenitor cell; Biology; Stem cell; Haematopoiesis; Immunology; Cell biology; Transcription factor; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001691873,0.0003491624,0.0002865179,0.0003094359,0.0001929532,0.0001975655,0.0003093185,0.0003161791,0.002477875],"category_scores_gemma":[0.00009822099,0.0001446373,0.0002869268,0.000141324,0.0002626301,0.0001642343,0.0001519409,0.0007688082,0.0003145117],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002932037,"about_ca_system_score_gemma":0.0003715312,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007967178,"about_ca_topic_score_gemma":0.001331288,"domain_scores_codex":[0.9998616,0.00001597823,0.000009579944,0.0000290319,0.00003040925,0.00005339057],"domain_scores_gemma":[0.9999344,0.00001543058,0.00001782947,0.000009425543,0.000006477303,0.00001635868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001912076,0.00009550825,0.00007151539,0.00002581519,0.000006219729,0.00002017821,0.00001046649,0.0001107079,0.9973288,0.0003068849,0.0001075027,0.001725234],"study_design_scores_gemma":[0.00003667125,0.000520496,0.0006628253,0.000002959966,0.0000157591,0.0000786021,0.00001658095,0.0008151569,0.9957165,0.00006865625,0.002062272,0.000003446002],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904808,0.001299509,0.004297398,0.0001913018,0.0001364954,0.00005766155,0.0002769413,0.0002622472,0.002997702],"genre_scores_gemma":[0.9932334,0.0005870427,0.002252632,0.00005839991,0.0000140029,0.00004821811,0.0002672946,0.00002298915,0.00351596],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002477875,"threshold_uncertainty_score":0.008289337,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01718121206281325,"score_gpt":0.2732852702099089,"score_spread":0.2561040581470957,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}