{"id":"W3122788064","doi":"10.1101/2021.01.18.427223","title":"Surface GluA1 and glutamatergic transmission are increased in cortical neurons of a VPS35 D620N knock-in mouse model of parkinsonism and altered by LRRK2 kinase inhibition","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University; University of British Columbia","funders":"","keywords":"LRRK2; Parkinsonism; Cell biology; Vacuolar protein sorting; Glutamate receptor; Glutamatergic; Biology; Endosome; Neurodegeneration; Mutation; AMPA receptor; Phenotype; Missense mutation; Genetics; Receptor; Gene; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001723798,0.0008165042,0.0005172263,0.001237518,0.0002552258,0.0005070915,0.0003542214,0.000877541,0.00331338],"category_scores_gemma":[0.0001178212,0.0003806006,0.0003963579,0.000292893,0.0005296286,0.0003669563,0.0002941616,0.001160864,0.0007171418],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000553806,"about_ca_system_score_gemma":0.0002194496,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0016492,"about_ca_topic_score_gemma":0.001741132,"domain_scores_codex":[0.9997787,0.00001902993,0.00002774559,0.00006152676,0.00006376227,0.00004917767],"domain_scores_gemma":[0.999783,0.00002045994,0.00005965821,0.00001715222,0.00001997808,0.00009965767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002661604,0.00005583295,0.0001291415,0.00003107974,0.0000115539,0.000153421,0.00002266106,0.0000588889,0.9985037,0.0001117668,0.00008263166,0.0005731619],"study_design_scores_gemma":[0.0000619755,0.0003634092,0.005039774,0.00001732816,0.00004633347,0.0005334234,0.00006097993,0.001358291,0.9908042,0.0001956726,0.001508836,0.000009718954],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917549,0.001071144,0.002576382,0.0003423829,0.00008131286,0.00002636815,0.001579926,0.000331181,0.002236369],"genre_scores_gemma":[0.9798247,0.0008077796,0.003677423,0.0001675337,0.0000206457,0.00009504304,0.001295043,0.0001882655,0.01392362],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00331338,"threshold_uncertainty_score":0.01108438,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01541621521521454,"score_gpt":0.226778652653857,"score_spread":0.2113624374386425,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}