{"id":"W3122819530","doi":"10.20944/preprints201803.0149.v1","title":"Adaptive Mutations in Influenza A/California/07/2009 Enhance Polymerase Activity and Infectious Virion Production","year":2018,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University Health Network; Nova Scotia Health Authority; Hospital for Sick Children; Dalhousie University","funders":"University of Wisconsin-Madison","keywords":"Biology; Polymerase; Virology; Virulence; Polymerase chain reaction; Virus; Gene; Influenza A virus; Genome; Reverse genetics; Serial passage; Host adaptation; Mutation; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001736439,0.0004017575,0.0002396165,0.0001849062,0.0001162901,0.0002467755,0.0001865414,0.0002624424,0.0006020439],"category_scores_gemma":[0.000132144,0.0001852535,0.0002921681,0.0001113925,0.0001643007,0.0001141344,0.0001975904,0.000592237,0.000228576],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002967018,"about_ca_system_score_gemma":0.0001890309,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001522255,"about_ca_topic_score_gemma":0.003341161,"domain_scores_codex":[0.9998333,0.00001611996,0.00001685059,0.00004571793,0.00005277893,0.00003514236],"domain_scores_gemma":[0.9999094,0.00001568236,0.00003041059,0.00001142053,0.0000130719,0.00002001574],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003528981,0.00001845253,0.0003659301,0.00001386499,0.000005751527,0.00001115009,0.000005292308,0.00006159084,0.9986035,0.00001991953,0.00004009548,0.0008192991],"study_design_scores_gemma":[0.00001689869,0.0004851401,0.01489737,0.000008082504,0.00002893929,0.0002480712,0.00001744125,0.001667646,0.9803472,0.00003972005,0.002233307,0.00001007621],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952559,0.0006229794,0.002142946,0.00004463982,0.00001943652,0.00002643178,0.0005577049,0.00009454378,0.001235361],"genre_scores_gemma":[0.9916922,0.0005664027,0.004811094,0.00008860362,0.000009844622,0.00003598177,0.001293399,0.00005822755,0.001444239],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001522255,"threshold_uncertainty_score":0.003026783,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1554852439200476,"score_gpt":0.4291048280668991,"score_spread":0.2736195841468515,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}