{"id":"W3122819530","doi":"10.20944/preprints201803.0149.v1","title":"Adaptive Mutations in Influenza A/California/07/2009 Enhance Polymerase Activity and Infectious Virion Production","year":2018,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University Health Network; Nova Scotia Health Authority; Hospital for Sick Children; Dalhousie University","funders":"University of Wisconsin-Madison","keywords":"Biology; Polymerase; Virology; Virulence; Polymerase chain reaction; Virus; Gene; Influenza A virus; Genome; Reverse genetics; Serial passage; Host adaptation; Mutation; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001158512,0.0005401697,0.000805774,0.0006534776,0.0002688231,0.00003115067,0.0001998654,0.0004672146,0.0002963727],"category_scores_gemma":[0.003289433,0.0005449995,0.0001519247,0.0004271127,0.0006986609,0.0002541628,0.00166576,0.001854958,0.001309256],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006838057,"about_ca_system_score_gemma":0.0005247956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001934784,"about_ca_topic_score_gemma":0.0002928714,"domain_scores_codex":[0.9961513,0.0003708235,0.0006425749,0.001540065,0.0006643351,0.0006309164],"domain_scores_gemma":[0.997434,0.0001557462,0.0003911986,0.001169006,0.0006017382,0.0002482765],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001813203,0.0008503378,0.8792456,0.0007612497,0.0004778472,0.00005627244,0.00318538,0.0004301375,0.1057609,0.00001967196,0.0001006933,0.007298782],"study_design_scores_gemma":[0.001015037,0.0001717499,0.7285269,0.0007485718,0.0001404276,0.00003323516,0.000104588,0.000247241,0.266544,0.0009493167,0.001050734,0.0004681551],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909353,0.0007128721,0.0001206676,0.0007086004,0.0003893025,0.002499074,0.00008719218,0.0002342976,0.004312752],"genre_scores_gemma":[0.997081,0.000641468,0.0001777612,0.000280919,0.0004960718,0.0007925673,0.00002589558,0.00006287998,0.0004413947],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1607831,"threshold_uncertainty_score":0.9997001,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1554852439200476,"score_gpt":0.4291048280668991,"score_spread":0.2736195841468515,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}