{"id":"W3122823259","doi":"10.3389/fvets.2021.595983","title":"A Multi-Platform Metabolomics Approach Identifies Urinary Metabolite Signatures That Differentiate Ketotic From Healthy Dairy Cows","year":2021,"lang":"en","type":"article","venue":"Frontiers in Veterinary Science","topic":"Genetic and phenotypic traits in livestock","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Alberta Livestock and Meat Agency; Genome Alberta; University of Alberta","keywords":"Ketosis; Metabolite; Urine; Metabolomics; Metabolome; Internal medicine; Endocrinology; Dairy cattle; Urinary system; Medicine; Chemistry; Physiology; Biology; Animal science; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003505312,0.0003039477,0.0003725833,0.0001898817,0.0002567602,0.000114915,0.0008162199,0.0001899588,0.00001540373],"category_scores_gemma":[0.00008509179,0.0002949981,0.0001230671,0.0004761618,0.0006701191,0.00003757577,0.0005796528,0.0002629508,0.000003750441],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003836915,"about_ca_system_score_gemma":0.0003700007,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002345448,"about_ca_topic_score_gemma":0.00000381274,"domain_scores_codex":[0.9975256,0.0001369736,0.0003292906,0.001038387,0.0003572184,0.0006125049],"domain_scores_gemma":[0.9988306,0.00001773499,0.0001261363,0.0007475984,0.00008214759,0.0001958408],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0008861967,0.001164306,0.02329502,0.0001499721,0.0002198851,0.00007996064,0.001665295,0.002070439,0.9611006,0.0008716121,0.001223985,0.007272721],"study_design_scores_gemma":[0.001871691,0.0009100211,0.9476901,0.00003977165,0.00007830426,0.0001288077,0.002238734,0.002893682,0.03460116,0.002963629,0.00574632,0.0008377304],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9077473,0.02011884,0.06897021,0.00003441169,0.002435443,0.0002343802,0.00009591811,0.00002107396,0.0003424574],"genre_scores_gemma":[0.7393873,0.0004285758,0.2592609,0.0002180049,0.0001031383,0.00002445472,0.0001644415,0.00001966641,0.0003934937],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9264994,"threshold_uncertainty_score":0.9999502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03108861416077001,"score_gpt":0.2654701906777793,"score_spread":0.2343815765170093,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}