{"id":"W3122892082","doi":"10.1016/j.tim.2021.01.002","title":"When PARPs Meet Antiviral Innate Immunity","year":2021,"lang":"en","type":"review","venue":"Trends in Microbiology","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"National Natural Science Foundation of China","keywords":"Biology; PARP1; Innate immune system; ADP-ribosylation; Poly ADP ribose polymerase; DNA repair; DNA damage; Polymerase; Immunity; DNA; NAD+ kinase; Computational biology; Genetics; Cell biology; Immune system; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004368483,0.0005444999,0.003137555,0.000832108,0.00004764226,0.00001370851,0.0003032636,0.0008840582,0.002368356],"category_scores_gemma":[0.00004158271,0.0004615987,0.0006421943,0.0007585693,0.00029374,0.00003663731,0.0001737168,0.001111598,0.000151805],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004254543,"about_ca_system_score_gemma":0.0003732306,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005162476,"about_ca_topic_score_gemma":0.00008372615,"domain_scores_codex":[0.9968748,0.0009186555,0.0009531811,0.0006478467,0.0000599924,0.0005455167],"domain_scores_gemma":[0.9985165,0.0001763971,0.0003567656,0.0008253542,0.00005818603,0.00006678427],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003204395,0.0001807351,0.00003610345,0.001927899,0.0003587721,0.0002612292,0.0001399981,4.760654e-8,0.0004095891,0.0001578378,0.02656451,0.9699312],"study_design_scores_gemma":[0.001166275,0.0001283679,0.000009295009,0.008761331,0.0003348827,0.0009699368,0.00001198611,1.633921e-7,0.00009367486,0.0000461489,0.9881086,0.0003693545],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009931228,0.9909867,0.000005909315,0.0002388832,0.0007423144,0.0002580258,0.0003713194,0.00007042636,0.007227129],"genre_scores_gemma":[0.00005186546,0.9893343,0.0005893097,0.0004559303,0.0002723011,0.0001149583,0.004397904,0.00007725404,0.00470622],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9695619,"threshold_uncertainty_score":0.9997836,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08336648720866009,"score_gpt":0.4009151119154856,"score_spread":0.3175486247068255,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}