{"id":"W3122892082","doi":"10.1016/j.tim.2021.01.002","title":"When PARPs Meet Antiviral Innate Immunity","year":2021,"lang":"en","type":"review","venue":"Trends in Microbiology","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"National Natural Science Foundation of China","keywords":"Biology; PARP1; Innate immune system; ADP-ribosylation; Poly ADP ribose polymerase; DNA repair; DNA damage; Polymerase; Immunity; DNA; NAD+ kinase; Computational biology; Genetics; Cell biology; Immune system; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001191253,0.0009345294,0.001733732,0.0009268466,0.0002468588,0.002025427,0.000880475,0.001451083,0.007281594],"category_scores_gemma":[0.001452557,0.0003682967,0.0005875836,0.0009947958,0.0005790578,0.002633402,0.0009462279,0.004393523,0.003858329],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000660382,"about_ca_system_score_gemma":0.00109267,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000464173,"about_ca_topic_score_gemma":0.001360579,"domain_scores_codex":[0.9997228,0.00006743837,0.00003769304,0.00004020099,0.00008958969,0.00004227742],"domain_scores_gemma":[0.9995585,0.0002123496,0.00006547142,0.00001536505,0.0001026401,0.00004578402],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002534163,0.00005185272,0.0001211723,0.01123838,0.0001410851,0.0001418579,0.0000411561,0.0004397487,0.001715123,0.008565926,0.08641112,0.890879],"study_design_scores_gemma":[0.00009416162,0.0001565697,0.0002736701,0.003037252,0.0001337248,0.0003591832,0.00003729778,0.0001257985,0.0004328672,0.004267863,0.9910647,0.00001691984],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008743298,0.9957356,0.0002462815,0.001385832,0.0009051385,0.000006380305,0.00004233268,0.00001694175,0.001573939],"genre_scores_gemma":[0.001029349,0.9951798,0.0002476689,0.001471516,0.0008325308,0.00001183568,0.00006197943,0.000004099089,0.001161254],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.007281594,"threshold_uncertainty_score":0.02435941,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08336648720866009,"score_gpt":0.4009151119154856,"score_spread":0.3175486247068255,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}