{"id":"W3122917998","doi":"10.1038/s41590-020-00836-7","title":"Gut CD4+ T cell phenotypes are a continuum molded by microbes, not by TH archetypes","year":2021,"lang":"en","type":"article","venue":"Nature Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":181,"is_retracted":false,"has_abstract":false,"ca_institutions":"Vector Institute; Canadian Institute for Advanced Research; University of British Columbia","funders":"Boehringer Ingelheim Fonds; National Institute of General Medical Sciences; Harvard Stem Cell Institute; Harvard University; National Institute of Allergy and Infectious Diseases; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; U.S. Department of Health and Human Services","keywords":"Biology; Chromatin; GATA3; Transcriptome; Transcription factor; Cell biology; T cell; T helper cell; Effector; Immunology; Genetics; Gene expression; Gene; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002590829,0.0002578805,0.0003497439,0.0004303558,0.0003182206,0.001201883,0.0002146336,0.0004930047,0.002254061],"category_scores_gemma":[0.0004589326,0.0002547957,0.0002012589,0.0001839464,0.0007955987,0.0008363253,0.0006906063,0.001451448,0.0004122973],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001862234,"about_ca_system_score_gemma":0.000172076,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001288762,"about_ca_topic_score_gemma":0.0003362665,"domain_scores_codex":[0.9996988,0.00006533233,0.0000167962,0.00006376099,0.00006982742,0.00008554031],"domain_scores_gemma":[0.9997491,0.00004013103,0.00006213404,0.00005030953,0.00002918019,0.00006915159],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000792765,0.00003708465,0.01733924,0.0001269995,0.00003606902,0.0004714562,0.0002448549,0.0002078774,0.9533858,0.003812237,0.0006008431,0.02294482],"study_design_scores_gemma":[0.0003024594,0.002942241,0.5008741,0.0004323162,0.0002354108,0.007852702,0.005292898,0.004580847,0.415463,0.02824395,0.03363393,0.000146247],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886212,0.002449508,0.002676969,0.0006956985,0.00008485805,0.000007556565,0.0001804713,0.00007928225,0.005204475],"genre_scores_gemma":[0.994821,0.0009786986,0.00216145,0.0003009923,0.00005385451,0.00001327401,0.00009791359,0.00002945762,0.001543387],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002254061,"threshold_uncertainty_score":0.007540584,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003819736690432212,"score_gpt":0.2069041671001944,"score_spread":0.2030844304097622,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}