{"id":"W3122925102","doi":"10.3389/fendo.2020.604998","title":"Human Pluripotent Stem Cells: A Unique Tool for Toxicity Testing in Pancreatic Progenitor and Endocrine Cells","year":2021,"lang":"en","type":"article","venue":"Frontiers in Endocrinology","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"Breakthrough T1D Canada; Canadian Institutes of Health Research","keywords":"Induced pluripotent stem cell; Progenitor cell; Endocrine system; Stem cell; Progenitor; Enteroendocrine cell; Biology; Toxicity; Cancer research; Medicine; Bioinformatics; Cell biology; Internal medicine; Endocrinology; Embryonic stem cell; Biochemistry; Hormone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002035428,0.0002597201,0.0004309966,0.0001993661,0.00008889718,0.00002985231,0.0002560499,0.0001632938,0.000005688255],"category_scores_gemma":[0.0001082737,0.000284921,0.00007843127,0.0002313642,0.0001583365,0.000008816433,0.0003549006,0.0002648058,0.000001800893],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001066485,"about_ca_system_score_gemma":0.0001705442,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005256284,"about_ca_topic_score_gemma":0.0001447919,"domain_scores_codex":[0.9974622,0.0002798518,0.0004592817,0.0007766888,0.0001360117,0.0008859864],"domain_scores_gemma":[0.9992218,0.00006131803,0.00009118654,0.0004148211,0.0001139368,0.00009691394],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009411816,0.0001842702,0.05021475,0.0001987083,0.00005893272,0.0003267639,0.00004643382,0.0001657496,0.9433014,0.00004698898,0.001210723,0.004151142],"study_design_scores_gemma":[0.002181026,0.000397501,0.003534379,0.00004867254,0.00002016109,0.0001319227,0.0002897861,0.0007625951,0.9818856,0.0001928135,0.01022541,0.0003302032],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941312,0.002310421,0.001852963,0.0001470121,0.0003844081,0.0008947223,0.00004255071,0.00002069649,0.0002160469],"genre_scores_gemma":[0.9764729,0.0005366175,0.02010001,0.0001251107,0.0001500708,0.0004166346,0.00005345072,0.00004956472,0.002095624],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04668036,"threshold_uncertainty_score":0.9999603,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01950923090056667,"score_gpt":0.2650577604705103,"score_spread":0.2455485295699437,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}