{"id":"W3122925102","doi":"10.3389/fendo.2020.604998","title":"Human Pluripotent Stem Cells: A Unique Tool for Toxicity Testing in Pancreatic Progenitor and Endocrine Cells","year":2021,"lang":"en","type":"article","venue":"Frontiers in Endocrinology","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"Breakthrough T1D Canada; Canadian Institutes of Health Research","keywords":"Induced pluripotent stem cell; Progenitor cell; Endocrine system; Stem cell; Progenitor; Enteroendocrine cell; Biology; Toxicity; Cancer research; Medicine; Bioinformatics; Cell biology; Internal medicine; Endocrinology; Embryonic stem cell; Biochemistry; Hormone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002867869,0.0007756031,0.00074179,0.001786092,0.0004897845,0.00134394,0.0009511386,0.001336935,0.003366387],"category_scores_gemma":[0.002260208,0.0006317318,0.0007575275,0.001076118,0.000634774,0.0009779568,0.001261439,0.002128633,0.002264598],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003291433,"about_ca_system_score_gemma":0.0005530166,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004682149,"about_ca_topic_score_gemma":0.00073423,"domain_scores_codex":[0.99687,0.0006292497,0.0004187227,0.0004074731,0.001550815,0.0001237053],"domain_scores_gemma":[0.9987285,0.0004347702,0.0001770834,0.0002568749,0.0003121813,0.00009070052],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007238968,0.0001018039,0.0009260488,0.0006188255,0.00004421607,0.000550875,0.0001965332,0.0006084091,0.9288108,0.002056916,0.004357821,0.06165527],"study_design_scores_gemma":[0.0000499557,0.0006609972,0.002452367,0.0002453597,0.0001637901,0.001973621,0.0001199331,0.00316173,0.8424356,0.001932099,0.1467116,0.00009307336],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.07451716,0.027263,0.8419505,0.003624802,0.00243564,0.00261822,0.0111529,0.007443867,0.0289939],"genre_scores_gemma":[0.2886998,0.02886995,0.6334444,0.004071848,0.000783036,0.004771053,0.01514714,0.001506166,0.0227066],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.003366387,"threshold_uncertainty_score":0.01516688,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01950923090056667,"score_gpt":0.2650577604705103,"score_spread":0.2455485295699437,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}