{"id":"W3122927199","doi":"10.3390/biomedicines9020101","title":"Checkpoint Inhibitors and Hepatotoxicity","year":2021,"lang":"en","type":"review","venue":"Biomedicines","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Immune system; Cancer research; Immune checkpoint; Immunology; Mechanism (biology); Immunotherapy; Biology; Tumor microenvironment; Immune tolerance; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003041754,0.0004215264,0.002072804,0.0003130048,0.00005943515,0.00002270518,0.00007837248,0.0003760654,0.0002258399],"category_scores_gemma":[0.00008326482,0.0002736064,0.0005310824,0.0006359217,0.0003156723,0.00002898105,0.00007561428,0.0002734982,0.0000164301],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001281094,"about_ca_system_score_gemma":0.0004393619,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001006585,"about_ca_topic_score_gemma":0.000006490581,"domain_scores_codex":[0.9982033,0.00006506168,0.0007034263,0.0004805164,0.0002877407,0.0002599379],"domain_scores_gemma":[0.9990142,0.00008351303,0.0002372097,0.000402162,0.00006883692,0.000194108],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000251522,0.00005738562,0.0000355397,0.01614063,0.0004174791,0.0001430454,0.00003891212,1.222018e-10,0.00007207746,0.000005887482,0.008075139,0.9749888],"study_design_scores_gemma":[0.0006990493,0.0001877455,0.00004188279,0.0384178,0.001091306,0.001001167,0.00004431102,3.07271e-7,0.00004259136,0.000002300729,0.9582224,0.0002491515],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001161889,0.997281,0.000003827856,0.0003722657,0.000842457,0.0006946533,0.00002734441,0.00007153452,0.0005907117],"genre_scores_gemma":[0.00001357154,0.9967186,0.0001115006,0.0003112151,0.001217694,0.00006363622,0.000219427,0.00005472184,0.001289662],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9747396,"threshold_uncertainty_score":0.9999716,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05049969239815653,"score_gpt":0.3516006538446723,"score_spread":0.3011009614465157,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}