{"id":"W3122927199","doi":"10.3390/biomedicines9020101","title":"Checkpoint Inhibitors and Hepatotoxicity","year":2021,"lang":"en","type":"review","venue":"Biomedicines","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Immune system; Cancer research; Immune checkpoint; Immunology; Mechanism (biology); Immunotherapy; Biology; Tumor microenvironment; Immune tolerance; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002660032,0.000475621,0.0007226118,0.0009628077,0.0001582914,0.0005619732,0.000428257,0.0006532665,0.004495867],"category_scores_gemma":[0.0004560485,0.000141401,0.0004848292,0.0007729399,0.0002051721,0.0004740325,0.0003746197,0.00121167,0.001277178],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003536678,"about_ca_system_score_gemma":0.0004232774,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004623117,"about_ca_topic_score_gemma":0.001187482,"domain_scores_codex":[0.9998817,0.00002444918,0.00001997038,0.0000204808,0.0000391756,0.00001404347],"domain_scores_gemma":[0.9998494,0.00007431213,0.00003016153,0.000005106055,0.00003039861,0.00001059222],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0001691542,0.00007669022,0.0001691044,0.01642234,0.0001091658,0.000247663,0.00003897733,0.0003370078,0.002027009,0.002878953,0.02296005,0.9545639],"study_design_scores_gemma":[0.00006533684,0.000253201,0.001213272,0.005277967,0.0001616589,0.002683762,0.00003702888,0.0001162353,0.00151539,0.001670942,0.9869909,0.00001425781],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002540933,0.9981101,0.00007234343,0.0002005293,0.0001342584,0.000004609842,0.00001994594,0.000007505496,0.001196679],"genre_scores_gemma":[0.002897452,0.9950384,0.0001553659,0.0003643797,0.0001681812,0.000009548965,0.00005409929,0.000002376569,0.001310108],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004495867,"threshold_uncertainty_score":0.01504016,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05049969239815653,"score_gpt":0.3516006538446723,"score_spread":0.3011009614465157,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}