{"id":"W3122931378","doi":"10.1038/s41380-020-00999-7","title":"Current and future applications of induced pluripotent stem cell-based models to study pathological proteins in neurodegenerative disorders","year":2021,"lang":"en","type":"review","venue":"Molecular Psychiatry","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Induced pluripotent stem cell; Neuroscience; Pathological; Psychology; Medicine; Biology; Embryonic stem cell; Genetics; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008566469,0.0007980726,0.001170434,0.001448866,0.0001890136,0.001031429,0.0009699839,0.001256105,0.003961907],"category_scores_gemma":[0.0006784442,0.000215964,0.0004653308,0.001817837,0.0005006832,0.001540502,0.0006171124,0.001936869,0.00178482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005504692,"about_ca_system_score_gemma":0.00093978,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000742075,"about_ca_topic_score_gemma":0.001727633,"domain_scores_codex":[0.9998635,0.00002422172,0.00001796719,0.00002521123,0.00005346577,0.00001552344],"domain_scores_gemma":[0.9996392,0.0002051404,0.00003420794,0.00001170005,0.00007620941,0.00003347496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001277289,0.00008368372,0.0001413125,0.01256551,0.00008010357,0.0002162446,0.00003622021,0.000553127,0.004214527,0.007700485,0.02746777,0.9468133],"study_design_scores_gemma":[0.00003736015,0.0001109205,0.0006271508,0.002827313,0.0001677129,0.0009250982,0.00005654546,0.0001721689,0.001181881,0.00566315,0.9882068,0.00002390952],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00006911308,0.9985447,0.0002302428,0.0002792867,0.0001534315,0.000003342867,0.00002147944,0.000006902012,0.0006915641],"genre_scores_gemma":[0.0003633278,0.998621,0.0003237408,0.0001866623,0.0001154906,0.000005287734,0.00003200281,0.000001162427,0.0003513808],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003961907,"threshold_uncertainty_score":0.01325393,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02878182109912329,"score_gpt":0.3185271191707653,"score_spread":0.289745298071642,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}