{"id":"W3122932834","doi":"10.1093/jncics/pkaa122","title":"Applications of Circulating Tumor DNA in a Cohort of Phase I Solid Tumor Patients Treated With Immunotherapy","year":2020,"lang":"en","type":"article","venue":"JNCI Cancer Spectrum","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research; Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; Internal medicine; Circulating tumor DNA; Oncology; Immunotherapy; Mutation; Cohort; Cancer; Gene; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003235929,0.0001172996,0.0002230009,0.00003319406,0.0000197414,0.000005693541,0.0001228515,0.0000308175,0.00002873679],"category_scores_gemma":[0.000014295,0.0001124691,0.00005142558,0.0001977745,0.00005562312,0.000002580348,0.00003099346,0.00005273573,6.672528e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005548846,"about_ca_system_score_gemma":0.0002457043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007348808,"about_ca_topic_score_gemma":0.0002766011,"domain_scores_codex":[0.9992111,0.000009996023,0.0002790045,0.0002438802,0.0001011275,0.0001549011],"domain_scores_gemma":[0.9994574,0.000007386347,0.0002136121,0.0002032288,0.00006445138,0.00005397329],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007155073,0.0005616707,0.5201739,0.00009321608,0.0001576925,0.000005523165,0.0002405551,0.0009636676,0.4748731,0.0001397407,0.00008047327,0.001994966],"study_design_scores_gemma":[0.0062272,0.00147915,0.08865914,0.00006548536,0.00004764404,0.000002749211,0.00006211227,0.0003000359,0.9009488,0.00007233248,0.001857085,0.0002782745],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977733,0.0004748734,0.0006844982,0.0001105386,0.00002055577,0.0004767152,0.0002063229,0.000005130334,0.0002480106],"genre_scores_gemma":[0.999084,0.0001595516,0.0001342437,0.0002763568,0.00009334595,0.0001428253,0.00008003835,0.00002429828,0.000005366589],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4315148,"threshold_uncertainty_score":0.4586358,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00638626304408909,"score_gpt":0.2568247875589491,"score_spread":0.25043852451486,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}