{"id":"W3122932834","doi":"10.1093/jncics/pkaa122","title":"Applications of Circulating Tumor DNA in a Cohort of Phase I Solid Tumor Patients Treated With Immunotherapy","year":2020,"lang":"en","type":"article","venue":"JNCI Cancer Spectrum","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research; Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; Internal medicine; Circulating tumor DNA; Oncology; Immunotherapy; Mutation; Cohort; Cancer; Gene; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005878093,0.0001615261,0.0003736138,0.0005734065,0.0002990325,0.0006000764,0.0001785478,0.0002362329,0.001612725],"category_scores_gemma":[0.002228684,0.0001140634,0.0001539315,0.0004608419,0.0001809002,0.0003093687,0.0002838282,0.0003570838,0.0002552102],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002083156,"about_ca_system_score_gemma":0.0001850125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005203994,"about_ca_topic_score_gemma":0.0004191258,"domain_scores_codex":[0.9996617,0.00009248876,0.0000310802,0.0001104029,0.0000589414,0.00004539418],"domain_scores_gemma":[0.9985545,0.0004143349,0.0005773617,0.00009375452,0.0001341551,0.0002259],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007161844,0.00003998673,0.9925606,0.000009705737,0.00003201976,0.00009922613,0.00005867751,0.0001343448,0.002618927,0.00002433265,0.0001422593,0.003563739],"study_design_scores_gemma":[0.00005962362,0.001059529,0.994325,0.000007206588,0.00005450066,0.00113708,0.0001190914,0.001166858,0.001296639,0.00007610511,0.0006923816,0.000005924112],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991471,0.0001931089,0.0001363425,0.00002452969,0.000004166329,0.00001145035,0.0002208195,0.000005983532,0.0002564726],"genre_scores_gemma":[0.9994875,0.00003247572,0.00008673855,0.00002168528,0.00001138822,0.00001490942,0.0002492156,0.000002450366,0.00009348999],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001612725,"threshold_uncertainty_score":0.005395114,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00638626304408909,"score_gpt":0.2568247875589491,"score_spread":0.25043852451486,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}