{"id":"W3122980896","doi":"10.3389/fgene.2021.620859","title":"MeCP2: The Genetic Driver of Rett Syndrome Epigenetics","year":2021,"lang":"en","type":"review","venue":"Frontiers in Genetics","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":147,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health; University of Victoria","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Ontario Rett Syndrome Association","keywords":"MECP2; Rett syndrome; Epigenetics; Biology; Chromatin; Genetics; DNA methylation; Neuroscience; Alternative splicing; Computational biology; Bioinformatics; Gene isoform; Gene; Phenotype; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001300106,0.0004598182,0.0002783583,0.0003539336,0.0001802094,0.000314458,0.0002741544,0.0007598816,0.001767016],"category_scores_gemma":[0.0003846654,0.0001225033,0.0002226708,0.0002611975,0.0002948851,0.0002099716,0.0003273832,0.0005709798,0.0005553762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004181287,"about_ca_system_score_gemma":0.0002826591,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001759649,"about_ca_topic_score_gemma":0.001490961,"domain_scores_codex":[0.9998719,0.00001431334,0.000008997248,0.00004203513,0.00004152532,0.00002139102],"domain_scores_gemma":[0.999927,0.00001754962,0.00002454709,0.000003885121,0.00001362864,0.00001340144],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005779382,0.00003090503,0.03243687,0.001221077,0.0003254706,0.06050156,0.0005097019,0.0009578746,0.6769415,0.01295551,0.01060049,0.202941],"study_design_scores_gemma":[0.0000994284,0.000377444,0.1252299,0.0007086111,0.0007638034,0.3440758,0.0006128735,0.003236512,0.2742599,0.01066327,0.2398264,0.0001460808],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.7338505,0.2062511,0.01611062,0.008492611,0.0008806369,0.00007326315,0.003042858,0.001099354,0.03019899],"genre_scores_gemma":[0.952348,0.03384934,0.003652143,0.0008004821,0.0003257988,0.00002286738,0.0007308822,0.00008495177,0.00818557],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.001767016,"threshold_uncertainty_score":0.005911231,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01533603506625677,"score_gpt":0.2582350462493514,"score_spread":0.2428990111830946,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}