{"id":"W3122980896","doi":"10.3389/fgene.2021.620859","title":"MeCP2: The Genetic Driver of Rett Syndrome Epigenetics","year":2021,"lang":"en","type":"review","venue":"Frontiers in Genetics","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":147,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health; University of Victoria","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Ontario Rett Syndrome Association","keywords":"MECP2; Rett syndrome; Epigenetics; Biology; Chromatin; Genetics; DNA methylation; Neuroscience; Alternative splicing; Computational biology; Bioinformatics; Gene isoform; Gene; Phenotype; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002265607,0.0006659928,0.001440216,0.0002076411,0.00008508714,0.00003794373,0.001154414,0.0006710609,0.00002198907],"category_scores_gemma":[0.00007447728,0.0005598877,0.0006028655,0.0005692873,0.0003344383,0.000001539807,0.0006390256,0.0003944207,0.000007882512],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005078369,"about_ca_system_score_gemma":0.0006220177,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003993128,"about_ca_topic_score_gemma":0.00002521114,"domain_scores_codex":[0.9966037,0.000376557,0.001131042,0.0009034034,0.0004000323,0.0005852749],"domain_scores_gemma":[0.9979327,0.00002982662,0.0004628692,0.001338289,0.0001142659,0.0001220763],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001238463,0.000245844,0.003064484,0.003930705,0.0008192581,0.0001182375,0.0001218946,0.0004220111,0.0003468387,0.00001287045,0.02264384,0.9682617],"study_design_scores_gemma":[0.0002806095,0.0001947747,0.001956198,0.001147921,0.0004129457,0.0001220229,0.0000837777,0.00001683594,0.0003128951,0.00005634827,0.9947531,0.0006626075],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003754066,0.9925825,0.001047391,0.00001851001,0.001393877,0.0008812507,0.00008901512,0.00000654467,0.0002268619],"genre_scores_gemma":[0.0007680056,0.9844525,0.01347422,0.0000892349,0.00005585821,0.00009775112,0.0003223825,0.0001510973,0.0005889644],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9721092,"threshold_uncertainty_score":0.9996853,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01533603506625677,"score_gpt":0.2582350462493514,"score_spread":0.2428990111830946,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}