{"id":"W3123070788","doi":"10.1002/trc2.12124","title":"Apolipoprotein E4–driven effects on inflammatory and neurotrophic factors in peripheral extracellular vesicles from cognitively impaired, no dementia participants who converted to Alzheimer's disease","year":2021,"lang":"en","type":"article","venue":"Alzheimer s & Dementia Translational Research & Clinical Interventions","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut National de la Recherche Scientifique","funders":"Ministère des relations internationales et de la Francophonie","keywords":"Apolipoprotein E; Neuroinflammation; Dementia; Neurotrophic factors; Biomarker; Medicine; Brain-derived neurotrophic factor; Inflammation; Immunology; Neuroscience; Disease; Internal medicine; Psychology; Biology; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001084455,0.0003600521,0.0003890142,0.0001797551,0.0002781737,0.0001468115,0.0003950903,0.0002183878,0.0005020404],"category_scores_gemma":[0.00105432,0.0003913606,0.0005605254,0.000287807,0.0004308675,0.00004793529,0.0003066889,0.0005874936,0.00009722402],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001295906,"about_ca_system_score_gemma":0.0003641309,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001166561,"about_ca_topic_score_gemma":0.0004689426,"domain_scores_codex":[0.9941258,0.002000723,0.001143838,0.001170524,0.0007760476,0.00078306],"domain_scores_gemma":[0.9972207,0.0006110968,0.0001400294,0.0005990331,0.0004864815,0.000942657],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002863948,0.004040212,0.7410823,0.0001463971,0.01271477,0.0006527575,0.0002564109,0.0003221619,0.2072138,0.000658147,0.001408946,0.02864012],"study_design_scores_gemma":[0.002966397,0.0007965622,0.9273738,0.0005518401,0.002200875,0.00000120022,0.0000666484,0.00195152,0.06049262,0.001056792,0.002013459,0.0005283405],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.958869,0.03731266,0.001006835,0.0009752538,0.0002203361,0.001204303,0.0003473003,0.00002580966,0.00003848021],"genre_scores_gemma":[0.9971489,0.0002826893,0.0006504987,0.0002431191,0.0003087714,0.0003407138,0.0009181453,0.00006837709,0.00003876538],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1862915,"threshold_uncertainty_score":0.9998538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1371250219534406,"score_gpt":0.4143701873245222,"score_spread":0.2772451653710816,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}