{"id":"W3123083777","doi":"10.1016/j.omto.2021.01.007","title":"A survivin-driven, tumor-activatable minicircle system for prostate cancer theranostics","year":2021,"lang":"en","type":"article","venue":"Molecular Therapy — Oncolytics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; London Health Sciences Centre; Robarts Clinical Trials; Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Western University; Prostate Cancer Canada","keywords":"Minicircle; Survivin; Prostate cancer; Cancer research; Cytosine deaminase; Cancer; Biology; Reporter gene; Suicide gene; Medicine; Molecular biology; Genetic enhancement; Gene; Gene expression; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003245825,0.0005750094,0.0003816808,0.0004148977,0.0002138258,0.0004141029,0.0004369885,0.0005682297,0.0008144691],"category_scores_gemma":[0.0004040776,0.0003000237,0.0003597754,0.0002609262,0.0003008558,0.0003791501,0.0002895457,0.0009908925,0.0006795443],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004196259,"about_ca_system_score_gemma":0.0004208928,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003564909,"about_ca_topic_score_gemma":0.0004345943,"domain_scores_codex":[0.9996316,0.00005851197,0.00003357507,0.0001164584,0.0001170963,0.00004263097],"domain_scores_gemma":[0.9997626,0.00003137108,0.00008551241,0.00002938424,0.00004489206,0.00004611835],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004811534,0.00002378917,0.00008562351,0.00008400624,0.000006773122,0.00003211417,0.0000215141,0.0001067528,0.9933137,0.0004356063,0.000201543,0.005640464],"study_design_scores_gemma":[0.00001485377,0.000419245,0.0005474142,0.000008285461,0.00003074485,0.000460095,0.000006872702,0.001032587,0.985443,0.0000493442,0.01197279,0.00001481439],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5306166,0.01888224,0.436657,0.0009255735,0.0006762251,0.001307946,0.001975836,0.003431758,0.005526786],"genre_scores_gemma":[0.8238904,0.007620171,0.1520847,0.0004915037,0.0001395625,0.0006132885,0.004448401,0.0002149372,0.01049707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008144691,"threshold_uncertainty_score":0.003044665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01690513710680298,"score_gpt":0.2800677928765921,"score_spread":0.2631626557697891,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}