{"id":"W3123083777","doi":"10.1016/j.omto.2021.01.007","title":"A survivin-driven, tumor-activatable minicircle system for prostate cancer theranostics","year":2021,"lang":"en","type":"article","venue":"Molecular Therapy — Oncolytics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; London Health Sciences Centre; Robarts Clinical Trials; Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Western University; Prostate Cancer Canada","keywords":"Minicircle; Survivin; Prostate cancer; Cancer research; Cytosine deaminase; Cancer; Biology; Reporter gene; Suicide gene; Medicine; Molecular biology; Genetic enhancement; Gene; Gene expression; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001536908,0.0002821362,0.0003152958,0.00003687697,0.0001259647,0.00008294087,0.0002744335,0.0001623308,0.00002487485],"category_scores_gemma":[0.00005830003,0.0002834635,0.0002334817,0.0001596727,0.00005969263,0.000005355384,0.0000855753,0.0001099344,0.000013525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007601649,"about_ca_system_score_gemma":0.0005166254,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004988802,"about_ca_topic_score_gemma":0.0000704213,"domain_scores_codex":[0.9983496,0.0001046476,0.0003286313,0.0005544686,0.0002095193,0.0004531241],"domain_scores_gemma":[0.9985801,0.00003389742,0.0001471957,0.0006250222,0.0004987394,0.0001150571],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003439114,0.0001536528,0.0007834154,0.00007913447,0.0003014003,0.00005381227,0.0001077122,0.001241657,0.9907861,0.00008935075,0.001164121,0.004895769],"study_design_scores_gemma":[0.001598581,0.0005431501,0.0001317002,0.00009013023,0.00004318185,0.00003479588,0.0003564471,0.001102033,0.9312506,0.00004323731,0.06443281,0.0003733004],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9804513,0.005822733,0.01130237,0.0002462151,0.0005887345,0.0006408626,0.0002370826,0.00003628277,0.0006743651],"genre_scores_gemma":[0.9932347,0.001191864,0.001559123,0.001419625,0.0002720683,0.0002583787,0.0002095549,0.00009035047,0.00176432],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06326869,"threshold_uncertainty_score":0.9999617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01690513710680298,"score_gpt":0.2800677928765921,"score_spread":0.2631626557697891,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}