{"id":"W3123144499","doi":"10.1101/2021.01.17.427005","title":"Intact synapse structure and function after combined knockout of PTPδ, PTPσ and LAR","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Helmholtz Zentrum München; National Cancer Institute; National Institutes of Health; INFRAFRONTIER; Dana-Farber/Harvard Cancer Center; Hospital for Sick Children; Giovanni Armenise-Harvard Foundation","keywords":"Active zone; Synapse; Postsynaptic potential; Synaptic vesicle; Excitatory postsynaptic potential; Cell biology; Protein tyrosine phosphatase; Biology; Neuroscience; Knockout mouse; Neurotransmission; Chemistry; Inhibitory postsynaptic potential; Receptor; Vesicle; Signal transduction; Membrane; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003587361,0.000719903,0.000744352,0.001067286,0.0003340072,0.0006226022,0.0005755448,0.0007928016,0.002860606],"category_scores_gemma":[0.0002755527,0.0004719736,0.0004970926,0.0003027846,0.0008265037,0.0003542062,0.0006891913,0.001162296,0.0009877124],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000430234,"about_ca_system_score_gemma":0.000365873,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001155236,"about_ca_topic_score_gemma":0.001619906,"domain_scores_codex":[0.9993025,0.00005193427,0.0001122905,0.0001531712,0.0002514113,0.000128688],"domain_scores_gemma":[0.9990531,0.0001144662,0.0003693157,0.00009447429,0.00007140781,0.0002972495],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000848603,0.00001145659,0.0001615213,0.00001823702,0.00000974051,0.0001526542,0.00001051336,0.00004545394,0.9989305,0.00009358914,0.00001658235,0.000464846],"study_design_scores_gemma":[0.00002382785,0.000118196,0.006422519,0.00001298184,0.00005196079,0.0009906918,0.00006418658,0.0007598169,0.990649,0.00009023419,0.0008055539,0.00001102226],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903706,0.0008785495,0.005732341,0.000111055,0.00005099823,0.00002548602,0.001086596,0.0002407676,0.001503602],"genre_scores_gemma":[0.9913168,0.0004478295,0.002749772,0.000048218,0.00001075178,0.0000430363,0.0006249687,0.0001732811,0.004585448],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002860606,"threshold_uncertainty_score":0.009569705,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01837107302655163,"score_gpt":0.2528929647811237,"score_spread":0.234521891754572,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}